摘要
目的研究鼻息肉伴变应性鼻炎患者白细胞介素水平与鼻息肉复发的关系,进一步阐明其发病机制,为临床防治提供参考。方法选取成都市第二人民医院耳鼻咽喉科行鼻内镜手术治疗的鼻息肉伴变应性鼻炎手术后,根据鼻息肉有无复发,将患者分为未复发组和复发组,未复发组患者20例(A组),复发组患者20例(B组),另将鼻中隔偏曲伴下鼻甲肥大患者20例设为对照组。术前、术后1周各组患者均抽取空腹静脉血检测白细胞介素-8(interleukin-8,IL-8)、白细胞介素-16(interleukin-16,IL-16)、白细胞介素-17(interleukin-17,IL-17)水平,鼻息肉切除术中保留息肉头端组织,对照组患者术中取部分下鼻甲黏膜组织,采用免疫组织化学方法(SP法)检测IL-8、IL-16、IL-17表达。采用Pearson多重线性分析IL-8、IL-16、IL-17水平与伴变应性鼻炎的鼻息肉复发患者的相关性。结果术前A、B组血清IL-8、IL-16、IL-17水平均高于对照组,差异具有统计学意义(P<0.05)。术后A、B组血清IL-8、IL-16、IL-17较术前明显降低,差异具有统计学意义(P<0.05)。B组术后IL-8、IL-17水平明显高于对照组及A组,差异具有统计学意义(P<0.05)。术后1周B组鼻息肉组织中IL-8、IL-16、IL-17中、强阳性表达率分别为60.0%、75.0%和80.0%,明显高于A组的45.0%、50.0%和60.0%,差异具有统计学意义(P<0.05)。A组和B组鼻息肉组织中IL-8、IL-16、IL-17中、强阳性表达率均高于对照组的0.0%、0.0%和0.0%,差异有统计学意义(P<0.05)。IL-8、IL-16、IL-17与伴变应性鼻炎鼻息肉的发生呈正相关(r=0.716、0.917、0.903,P均=0.000);与鼻息肉复发呈正相关(r=0.527、0.763、0.842,P=0.014、0.000、0.000)。结论伴变应性鼻炎鼻息肉患者的血清与鼻息肉组织中白细胞介素水平和表达明显升高,息肉组织中白细胞介素高表达与复发呈正相关,提示应采取有效措施消除局部炎症,降低鼻息肉的复发率。
Objective To study the relationship between interleukin level and nasal polyp recurrence in patients with allergic rhinitis and nasal polyps,and to further clarify its pathogenesis,so as to provide reference for clinical prevention and treatment.Methods Sixty patients of nasal polyp patients with allergic rhinitisin were selected as the study subjects,which were treated with nasal endoscopic surgery in the department of otolaryngology of the second people's hospital of chengdu.According to the postoperative recurrence of nasal polyps,patients were divided into without relapse group(group A)20 cases and with recurrence group(group B)20 cases.In addition,20 patients with deviated nasal septum accompanied by hypertrophy of inferior turbinate were set as the control group.Preoperative and postoperative 1 week each patient needs extracting fasting venous blood detection of interleukin 8(interleukin-8,IL-8),interleukin-16(interleukin-16,IL-16)and interleukin-17(interleukin-17,IL-17).In nasal polypectomy,the front tissues of the polyp were preserved.The IL-8,IL-16 and IL-17 expressions of the inferior turbinate mucosa tissues taken intraoperatively in the control group were detected by immunohistochemical method(SP).Pearson multiple linear analysis was performed to determine the correlation between IL-8,IL-16 and IL-17 levels and recurrence of nasal polyps with allergic rhinitis.Results The IL-8,IL-16 and IL-17 levels of preoperative serum of group A and B were higher than those of the control group,and the difference was statistically significant(P<0.05).The IL-8,IL-16 and IL-17 levels of postoperative serum of group A and B were significantly reduced,which were compared with those of the preoperation,and the difference was statistically significant(P<0.05).The positive rates of IL-8,IL-16 and IL-17 expressions were 60.0%,75.0%and 80.0%respectively in group B tissues,which were significantly higher than that of 45.0%,50.0%and 60.0%in group A tissues,and the difference was statistically significant(P<0.05).The moderate-
作者
陈佳
CHEN Jia(Department of Otolaryngology,the Second People’s Hospital of Chengdu,Chengdu 610017,China)
出处
《中国耳鼻咽喉颅底外科杂志》
CAS
2019年第5期537-541,共5页
Chinese Journal of Otorhinolaryngology-skull Base Surgery
关键词
变应性鼻炎
鼻息肉
白细胞介素
复发
关系
Allergic rhinitis
Nasal polyps
Interleukin
Recurrence
Relationship
