摘要
目的:探讨呼吸窘迫综合征(RDS)早产儿血清维生素A(VA)、降钙素原(PCT)、肿瘤坏死因子-α(TNF-α)及C反应蛋白(CRP)水平的表达及临床意义。方法:选取2015年2月~2018年5月期间青岛市妇女儿童医院收治的90例RDS早产儿纳入观察组,根据RDS分级将观察组分为轻度组48例,中重度组42例。另选取同期于本院出生的非RDS早产儿35例作为对照组。根据血清VA水平将125例早产儿分为VA缺乏组(n=72),亚临床VA缺乏组(n=36),正常组(n=17)。比较观察组与对照组、轻度组与中重度组早产儿血清VA、PCT、TNF-α及CRP水平,比较不同血清VA水平早产儿的RDS发病情况,分析观察组早产儿血清VA与PCT、TNF-α及CRP水平的相关性。结果:观察组早产儿血清VA水平明显低于对照组(P<0.05),而观察组早产儿血清PCT、TNF-α、CRP明显高于对照组(P<0.05)。中重度组早产儿血清VA水平与轻度组比较差异无统计学意义(P>0.05),而中重度组早产儿血清PCT、TNF-α、CRP水平明显高于轻度组(P<0.05)。随着血清VA水平的升高,RDS发病率逐渐降低,组间比较差异有统计学意义(P<0.05)。Pearson相关性分析显示,观察组早产儿血清VA与PCT、TNF-α及CRP水平无显著相关性(P>0.05)。结论:RDS早产儿血清VA与PCT、TNF-α及CRP水平均存在明显异常,但四者无明显相关性,血清VA相对较低者更易发生RDS,临床可通过及时干预VA水平以降低RDS的发生风险。
Objective: To investigate the expression and clinical significance of serum vitamin A(VA),procalcitonin(PCT),tumor necrosis factor-α(TNF-α) and C-reactive protein(CRP) in premature infants with respiratory distress syndrome(RDS). Methods:90 cases of preterm infants with RDS who were admitted to Qingdao Women’s and Children’s Hospital from February 2015 to May 2018 were selected as the observation group.According to RDS classification, the observation group was divided into mild group(48 cases)and moderate and severe group(42 cases). Another 35 non RDS preterm infants in our hospital in the same period were selected as control group. According to serum VA level, 125 cases of preterm infants were divided into VA deficiency group(n=72), subclinical VA deficiency group(n=36) and normal group(n=17). The serum VA, PCT, TNF-α and CRP levels were compared between the observation group and the control group, the mild group and the moderate and severe group. The incidence of RDS in preterm infants with different serum VA levels was compared. The correlation between serum VA and PCT, TNF-α and CRP levels in premature infants were analyzed. Results: The serum VA level of preterm infants in the observation group was significantly lower than that in the control group(P<0.05), while the serum PCT, TNF-α and CRP in the observation group were significantly higher than those in the control group(P<0.05). There was no significant difference in serum VA level between moderate and severe group and mild group(P>0.05). Serum PCT,TNF-a and CRP in moderate and severe group were significantly higher than those in mild group(P<0.05). With the increase of serum VA level, the incidence of RDS decreased, and there was significant difference between groups(P<0.05). Pearson correlation analysis showed that there was no significant correlation between serum VA and PCT, TNF-α and CRP levels in preterm infants in the observation group(P>0.05). Conclusion: There are obvious abnormalities in serum VA, PCT, TNF-α and CRP levels in preterm
作者
阎丽华
宁伟伟
江倩男
张立生
魏东旭
YAN Li-hua;NING Wei-wei;JIANG Qian-nan;ZHANG Li-sheng;WEI Dong-xu(Neonatal Intensive Care Unit,Qingdao Women and Children Hospital,Qingdao,Shandong,266000,China)
出处
《现代生物医学进展》
CAS
2019年第20期3943-3946,共4页
Progress in Modern Biomedicine
基金
山东省医药卫生科技发展计划项目(2015SW1028)
关键词
呼吸窘迫综合征
早产儿
维生素A
降钙素原
肿瘤坏死因子-α
C反应蛋白
临床意义
Respiratory distress syndrome
Premature infants
Vitamin A
Procalcitonin
Tumor necrosis factor-a
C-reactive protein
Clinical significance
