摘要
Perthes病即儿童股骨头缺血性坏死,也曾被称为儿童股骨头骨软骨炎、股骨头无菌性坏死、股骨头无血管坏死等,反映了不同时期对本病的认识过程。该病具有一定的自愈倾向,部分患儿遗留股骨头畸形,可导致髋关节负重和活动功能障碍,甚至致残致畸,临床效果堪忧。虽然经过100多年的研究,但至今病因仍不清楚,发病机制不明,究其原因主要在于缺乏较理想的动物模型用于相应研究。多年来,国内外学者做了众多努力和尝试,现就近年来Perthes病动物模型的相关研究进展作一综述,以期为广大小儿骨科工作者进一步认识该病提供参考。
Perthes disease is the ischemic necrosis of femoral head in children.It was also called osteochondrositis of femoral head in children,aseptic necrosis of femoral head,avascular necrosis of femoral head,etc.,which reflected people′s understanding of this disease in different periods.The disease has a certain tendency of self-healing.The femoral head deformity left behind by some of the children may lead to the hip joint weight-bearing and mobility dysfunction,or even disability and deformity,and the clinical effect is worrying.Despite more than 100 years of research,the etiology and pathogenesis are still unclear,mainly due to the lack of ideal animal models for the corresponding research.Over the years,many efforts and attempts have been made by scholars.At present,the recent studies on animal model of Perthes disease have been reviewed in order to provide references for children′s orthopaedic doctors to further understand this disease.
作者
俞洋
俞松
Yu Yang;Yu Song(School of Pediatrics,Nanjing Medical University,Nanjing 210008,China;Department of Pediatric Orthopedics,Affiliated Hospital of Zunyi Medical University,Zunyi 563003,Guizhou Province,China)
出处
《中华实用儿科临床杂志》
CSCD
北大核心
2019年第20期1598-1600,共3页
Chinese Journal of Applied Clinical Pediatrics
基金
贵州省科学技术基金重点项目(黔科合基础(2018)1430)。
