摘要
目的研究运动性股骨头缺血坏死幼年动物模型的制作方法。方法共选取健康幼年雄性新西兰大白兔10只，均经X线检查证实骨骺未闭。对实验兔右侧髋关节进行大范围、高强度被动运动及股骨头向心性撞击，左侧为自身对照侧，未给予特殊处理。经4周干预后对实验兔双侧髋关节进行X线、MRI检查，随后取双侧股骨头标本进行大体肉眼观及组织学检查，以了解股骨头坏死情况。结果幼年新西兰大白兔经4周干预后，通过X线检查发现其运动侧股骨头局部密度增高，骨骺高度降低，骨小梁模糊；MRI检查发现运动侧髋关节囊内积液，T1和T2相均可见股骨头内有片状低密度信号区；组织学检查显示运动侧骨小梁稀疏、变细、断裂，骨小梁排列不规则。结论对幼年新西兰大白兔髋关节进行大范围被动运动及股骨头向心性撞击，可成功复制出股骨头缺血性坏死幼年动物模型。
Objective To establish an immature rabbit model of avascular necrosis of the femoral head induced by exercise. Methods Ten male, immature New Zealand white rabbits were subjected to large range, intense passive movement and concentric impingement on their right hips for 4 weeks. The left hips were used as selfcontrols. Then X-ray and magnetic resonance imaging, gross anatomical observation and histological examination were used to evaluate avascular necrosis of the femoral head. Result After 4 weeks, avascular necrosis of the femoral head was successfully replicated. Increased bone density, decreased osteoepiphysis height and indistinct bone trabecula were found in X-rays of the right hips. In MRI images obvious joint hydrops could be detected in all right hips, and schistic low signal areas in the femoral head could be seen in T1W1 and T2W1 images. Thin bone trabeculae of low density, with irregular and broken structures, were also found in H-E sections. Conclusion An immature rabbit model of avascular necrosis of femoral head can be successfully induced through large range, intense, passive movement and concentric impingement.
出处
《中华物理医学与康复杂志》
CAS
CSCD
北大核心
2009年第4期224-227,共4页
Chinese Journal of Physical Medicine and Rehabilitation
基金
浙江省体育局自然基金项目（浙体科[2006]477号）
关键词
股骨头缺血性坏死
幼年兔
运动
Avascular necrosis of the femoral head
Immature rabbits
Exercise
