摘要
目的:探讨活血化瘀软坚散结法治疗子宫内膜异位症患者的疗效及对体液免疫因子的影响。方法:选取2017年6—12月南京中医药大学第一临床医学院收治的子宫内膜异位症患者90例作为研究对象,按照随机数字表法随机分为对照组和观察组,每组45例。对照组采用孕三烯酮胶囊口服治疗,观察组在此基础上给予活血化瘀软坚散结法治疗,持续治疗6个月。观察2组患者临床疗效、血液流变学指标以及免疫球蛋白(IgA、IgG、IgM)和补体(C3)水平。结果:观察组治疗后中医证候积分(6.05±2.21)分和痛经症状评分(3.81±1.03)分下降大于比对照组[(7.56±2.57)分,(4.56±1.27)分],差异有统计学意义(P<0.05);观察组的全血高切黏度、全血低切黏度、血浆比黏度、红细胞刚性指数和红细胞聚集指数各指标均显著低于对照组,差异有统计学意义(P<0.05);观察组IgA(1.38±0.16)g/L、IgG(4.89±0.56)g/L、IgM(1.14±0.18)g/L和C3(1.35±0.22)g/L均较治疗前下降,且下降程度较对照组显著,差异有统计学意义(P<0.05);观察组的治疗有效率高达93.75%,而对照组仅为79.17%,差异有统计学意义(P<0.05)。结论:活血化瘀软坚散结法治疗子宫内膜异位症可有效缓解患者症状,调节体液免疫,效果显著。
Objective:To investigate the therapeutic effects of the method of activating blood circulation,resolving blood stasis,softening and resolving hard mass in treating endometriosis,and observe its effects on humoral immune factors.Methods:A total of 90 patients with endometriosis admitted to The First Clinical Medical College of Nanjing University of Chinese Medicine from June to December 2017 were selected and randomly divided into an observation group and a control group,with 45 cases in each group.The control group was treated with gestrinone capsules orally.On the basis of this,the observation group was given activating blood circulation,resolving blood stasis,softening and resolving hard mass,and continued treatment for 6 months.The clinical efficacy,hemorheological index as well as immunoglobulin(IgA,IgG,IgM)and complement(C3)levels of the 2 groups were observed.Results:After treatment,the scores of TCM symptom scores(6.05±2.21)and dysmenorrhea symptom scores(3.81±1.03)in the observation group were significantly decreased than those in the control group[(7.56±2.57),(4.56±1.27)](P<0.05);the whole blood high-viscosity,whole blood low-cut viscosity,plasma specific viscosity,erythrocyte rigidity index and erythrocyte aggregation index of the observation group were significantly lower than those of the control group(P<0.05);IgA(1.38±0.16)g/L,IgG(4.89±0.56)g/L,IgM(1.14±0.18)g/L and C3(1.35±0.22)g/L in the observation group decreased when compared with that before treatment,and the degree of decline was significantly higher than the control group(P<0.05);the total effective rate of the observation group was as high as 93.75%,while the control group was only 79.17%.The difference was statistically significant(P<0.05).Conclusion:The treatment of endometriosis with the method of activating blood circulation,resolving blood stasis,softening and resolving hard mass can effectively alleviate the symptoms of patients and regulate humoral immunity.The effect is significant and it is worth further promotion and applic
作者
庞佳欢
夏亲华
Pang Jiahuan;Xia Qinhua(The First Clinical Medical College of Nanjing University of Chinese Medicine,Nanjing 210000,China;Department of Gynecology,Jiangsu Province Traditional Chinese Medicine Hospital,Nanjing 210000,China)
出处
《世界中医药》
CAS
2019年第10期2711-2715,共5页
World Chinese Medicine
基金
江苏省自然科技基金项目(BK20151573)——内异停方对PD-1/PD-1L通路在EMS免疫逃逸的干预作用—人源化裸鼠EMS模型的应用
关键词
活血化瘀软坚散结法
子宫内膜异位症
中医药疗法
体液免疫
免疫球蛋白
补体
痛经症状
血液流变学
Method of activating blood circulation
resolving blood stasis
softening and resolving hard mass
Endometriosis
Traditional Chinese medicine therapy
Humoral immunity
Immunoglobulin
Complement
Dysmenorrhea symptoms
Blood rheology
