摘要
目的 :观察乌司他丁对骨科病人凝血功能及血小板聚集的影响。方法 :选择 30例无血液疾病及凝血功能障碍、肝肾功能异常或服用相应药物的择期骨科病人 (ASAⅠ～Ⅱ ) ,随机分为乌司他丁组 (Ⅰ组 ,n =15 )和生理盐水组 (Ⅱ组 ,n =15 ) ;分别于给药前 (T0 )、给药后 1h(T1)、给药后 2h(T2 )采血测定凝血酶原时间 (PT)、部分凝血活酶时间 (APTT)、凝血酶时间 (TT)、纤维蛋白原 (FIB)、国际敏感指数 (INR)及血小板 1min ,5min最大聚集率(PAG1,PAG5 ,PAGM )。结果 :乌司他丁组用药后 1h ,APTT ,PT较用药前明显延长 (P <0 .0 5 ) ,用药后 2h ,TT较用药前明显延长 (P <0 .0 5 )。与对照组比较 ,用药后 1h ,APTT显著性延长 (P <0 .0 1) ,用药后 2h ,PT显著性延长(P <0 .0 5 )。两组用药前后及组间比较PAgT均差异无显著性 (P >0 .0 5 )。结论 :围术期中静脉滴注 5 0 0 0U /kg乌司他丁可改善术中患者的凝血状态 ,减少术中微血栓综合症 。
Objective To investigate the effect of ulinastatin (UTI)on human blood coagulation and platelet aggregation in orthopaedic surgery.Methods Thirty ASAⅠ～Ⅱpatients without blood dyscrasia and blood coagulation obstacle were randomly divided into two groups:GroupⅠ(UTI group,n=15)in which patients received UTI 5 000 U/kg, and Group Ⅱ(control group,n=15) in which patients received NS 100 ml. PT, TT, APTT, IB, INR and PAG1, PAG5, and PAGM were measured at 3 points:pre-infusion(T0),1 hour after the infusion (T1),and 2 hours after the infusion (T2).Results Compared with the saline group,APTT and PT of UTI group were prolonged significantly than the baseline (before infusion). In Group Ⅰ,after the infusion,APTT,TT and PT were prolonged significantly than before the infusion.Conclusion UTI 5 000 U/kg can ameliorate orthopaedic patients and blood coagulation status,which may reduce microthrombus syndrome in the operation and prevent venous thrombosis after the operation.
出处
《中南大学学报（医学版）》
CAS
CSCD
北大核心
2004年第5期569-571,共3页
Journal of Central South University ：Medical Science
