摘要
目的分析高通量血液透析(HFHD)在合并甲状旁腺功能亢进(SHPT)的尿毒症患者中的应用效果。方法选取郑州市第三人民医院2018年6月-2019年3月间就诊的60例合并SHPT的尿毒症患者作为观察对象,按照透析方式随机分为两组,以接受常规血液透析治疗者设为常规组,以接受HFHD治疗者设为HFHD组,每组30例。对比两组3个月治疗过程中肾功能及甲状旁腺功能变化情况。结果透析12周后,两组血肌酐(Scr)、尿素氮(BUN)及钙离子(Ca)均较入组时降低(P<0.05),且两组间比较未见统计学差异(P>0.05)。但常规组治疗前后甲状旁腺素(PTH)分别为(815.66±96.95)pg/mL、(711.06±90.18)pg/mL,无明显变化,差异无统计学意义(P>0.05),而HFHD组治疗前后甲状旁腺素分别为(809.53±91.13)pg/mL、(513.55±85.51)pg/mL,治疗后较治疗前明显降低(P<0.05),HFHD组透析12周后,PTH明显低于常规组(P<0.05)。结论在合并SHPT的尿毒症的治疗中高通量血液透析具有良好的应用效果。
Objective To analyze the effect of high throughput hemodialysis(HFHD) in uremia patients with hyperparathyroidism(SHPT).Methods Totally 60 cases of uremia patients with SHPT admitted to our hospital from June 2018 to March 2019 were selected as the observation objects. They were randomly divided into two groups according to the dialysis method. Those receiving routine hemodialysis were set as the routine group, and those receiving HFHD were set as the HFHD group, with 30 cases in each group. Changes in renal function and parathyroid function during 3 months of treatment were compared between the two groups.Results After 12 weeks of dialysis, serum creatinine(Scr), urea nitrogen(BUN) and calcium ions(Ca) were all decreased in the two groups compared with the group(P<0.05), and no statistical difference was found between the two groups(P>0.05). But regular group before and after treatment of parathyroid hormone(PTH), respectively(815.66±96.95) pg/ml,(711.06±90.18) pg/ml, no obvious changes, there was no statistically significant difference(P>0.05), while HFHD group before and after treatment respectively of parathyroid hormone(809.53±91.13) pg/ml,(513.55±85.51) pg/ml, significantly lower after treatment than before treatment(P<0.05), HFHD group of 12 weeks after dialysis, PTH significantly lower than normal group(P<0.05).Conclusion High-flux hemodialysis is effective in the treatment of uremia with SHPT.
作者
樊一筠
程艳
FAN Yi-yun;CHENG Yan(Zhengzhou the Third People's Hospital,Zhengzhou 450000,China)
出处
《医药论坛杂志》
2019年第10期60-62,共3页
Journal of Medical Forum
