摘要
目的探讨保乳术联合辅助化疗治疗乳腺癌术后患者乳房美容效果及对相关肿瘤标志物表达水平的影响。方法选取2016年1月至2018年12月间福建省肿瘤医院收治的100例乳腺癌手术患者进行回顾性分析。采用保乳术联合辅助化疗治疗的50例患者纳入观察组,采用改良根治术联合术后辅助化疗治疗的50例患者纳入对照组。比较两组患者术中出血量、手术时间、住院时间及术后并发症发生率,调查患者术后乳房美容效果并检测患者血清中YKL-40和TGF-β水平。结果观察组患者治疗术中出血量、手术时间、住院时间及并发症发生率均低于对照组,差异均有统计学意义(均P<0.05)。观察组患者术后美容效果优良率为82.0%,优于对照组患者的4.0%,差异有统计学意义(P<0.05)。治疗后,两组患者血清中YKL-40和TGF-β水平均降低,且观察组患者YKL-40和TGF-β水平均低于对照组患者,差异均有统计学意义(均P<0.05)。结论采用保乳术联合辅助化疗方案治疗乳腺癌患者,在保证治疗效果的同时,可提高乳房美观程度,并有效降低患者血清中YKL-40和TGF-β水平。
Objective To analyze the cosmetic results and expression of tumor markers after breast-conserving surgery combined with adjuvant chemotherapy for breast cancer.Methods One hundred patients with breast cancer admitted to Fujian Provincial Cancer Hopital from January 2016 to December 2018 were selected and retrospectively analyzed.They were randomly divided into an observation group and a control group with 50 patients in each group according to the treatment they received.The observation group was treated with breast-conserving surgery combined with adjuvant chemotherapy.The control group was treated with modified radical mastectomy combined with postoperative adjuvant chemotherapy.The intraoperative blood loss,operation time,length of hospital stay and postoperative complication rate were recorded.The postoperative cosmetic results of breast and therapeutic efficacy were investigated,and the serum levels of YKL-40 and TGF-βwere detected.Results The amount of bleeding,operation time,length of hospital stay and complication rate were lower in the observation group than in the control group(all P<0.05).The Excellent rate of cosmetic results was 82.0%in the observation group which was significantly better than 4.0%of the control group(P<0.05).After treatment,the levels of YKL-40 and TGF-βin the blood of the two groups significantly decreased(all P<0.05)with the levels significantly lower in the observation group than in the control group after treatment(all P<0.05).Conclusion Breast-conserving surgery combined with adjuvant chemotherapy for breast cancer treatment can significantly improve the cosmetic efficacy of the breast while effectively reducing the level of YKL-40 and TGF-βin the blood.
作者
黄丽英
黄凯
陈颖
陈夏
林佳
HUANG Li-ying;HUANG Kai;CHEN Ying;CHEN Xia;LIN Jia(Department of Breast Surgery,Fujian Provincial Cancer Hopital,Cancer Hopital Affiliated to Fujian Medical University,Fuzhou 350014,China)
出处
《中国肿瘤临床与康复》
2019年第10期1170-1173,共4页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
保乳术
辅助化疗
乳腺肿瘤
乳房美容
YKL-40
TGF-β
Breast-conserving surgery
Adjuvant chemotherapy
Breast neoplasms
Aesthetic procedure for breast remodelling
YKL-40
TGF-β
