摘要
目的观察奥扎格雷联合葛根素治疗急性脑梗死患者的临床疗效,并探讨其对病灶侧支循环的影响。方法选取2016-2018年徐州市中心医院神经内科收治的急性脑梗死患者160例,采用随机数字表法分为对照组和研究组,每组80例。两组患者入院后均给予常规治疗,对照组患者给予奥扎格雷治疗,研究组患者在对照组基础上给予葛根素治疗;两组患者均持续治疗2周。比较两组患者临床疗效,治疗前后日常生活活动能力量表(ADL)评分、美国国立卫生研究院卒中量表(NIHSS)评分、血清炎性因子〔包括白介素6(IL-6)、白介素8(IL-8)、超敏C反应蛋白(hs-CRP)及肿瘤坏死因子α(TNF-α)〕及血小板活化因子〔包括α颗粒膜糖蛋白(CD62p)、溶酶体颗粒膜糖蛋白(CD63)、血小板-单核细胞聚集体(PMA)〕水平、凝血功能指标〔包括凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)和纤维蛋白原(FIB)〕、病灶侧支循环微血管分级,并观察两组患者治疗期间不良反应发生情况。结果(1)研究组患者临床疗效优于对照组(P<0.05)。(2)两组患者治疗前ADL评分、NIHSS评分比较,差异无统计学意义(P>0.05);与对照组相比,研究组患者治疗后ADL评分升高,NIHSS评分降低(P<0.05)。(3)两组患者治疗前血清IL-6、IL-8、hs-CRP、TNF-α水平比较,差异无统计学意义(P>0.05);与对照组相比,研究组患者治疗后血清IL-6、IL-8、hs-CRP、TNF-α水平降低(P<0.05)。(4)两组患者治疗前血清CD62p、CD63、PMA水平比较,差异无统计学意义(P>0.05);与对照组相比,研究组患者治疗后血清CD62p、CD63、PMA水平降低(P<0.05)。(5)两组患者治疗前PT、APTT、FIB比较,差异无统计学意义(P>0.05);与对照组相比,研究组患者治疗后PT、APTT延长,FIB降低(P<0.05)。(6)两组患者治疗前病灶侧支循环微血管分级比较,差异无统计学意义(P>0.05);研究组患者治疗后病灶侧支循环微血管分级优于对照组(P<0.05
Objective To observe the clinical effect of ozagrel combined with puerarin on acute cerebral infarction,and to investigate the impact on collateral circulation around nidus.Methods From 2016 to 2018,a total of 160 patients with acute cerebral infarction were selected in the Department of Neurology,Xuzhou Central Hospital,and they were divided into control group and study group according to random number table method,with 80 cases in each group.Patients in the two groups received routine treatment after admission,moreover patients in control group were given ozagrel,while patients in study group were given puerarin based on that of control group;both groups were continuously treated for 2 weeks.Clinical effect,ADL score,NIHSS score,inflammatory cytokines(including IL-6,IL-8,hs-CRP and TNF-α),platelet activating factors(including CD62 p,CD63 and PMA),indicators of blood coagulation function(including PT,APTT and FIB)and microvascular classification of collateral circulation around nidus before and after treatment were compared between the two groups,and incidence of adverse drug reactions was observed during treatment.Results(1)Compared with that in control group,study group showed statistically significantly better clinical effect(P<0.05).(2)Compared with those in control group,study group showed similar ADL score and NIHSS score before treatment(P>0.05),statistically significantly higher ADL score but lower NIHSS score after treatment(P<0.05).(3)Compared with those in control group,study group showed similar serum levels of IL-6,IL-8,hs-CRP and TNF-αbefore treatment(P>0.05),statistically significantly lower serum levels of IL-6,IL-8,hs-CRP and TNF-αafter treatment(P<0.05).(4)Compared with those in control group,study group showed similar serum levels of CD62 p,CD63 and PMA before treatment(P>0.05),statistically significantly lower serum levels of CD62 p,CD63 and PMA after treatment(P<0.05).(5)Compared with those in control group,study group showed similar PT,APTT and FIB before treatment(P>0.05),statistically
作者
孟新颜
耿德勤
MENG Xinyan;GENG Deqin(Clinical College of Xuzhou Medical University,Xuzhou 221002,China;The Affiliated Hospital of Xuzhou Medical University,Xuzhou 221006,China)
出处
《实用心脑肺血管病杂志》
2019年第10期104-108,共5页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
脑梗死
奥扎格雷
葛根素
侧支循环
治疗结果
Brain infarction
Ozagrel
Puerarin
Collateral circulation
Treatment outcome
