摘要
细胞凋亡是一个重要的生物学过程,对细胞命运及稳态的调控起着关键作用。B细胞淋巴瘤-2(Bcl-2)家族蛋白是凋亡途径的重要组分,其功能异常与多种疾病相关,包括癌症、神经退行性疾病和自身免疫疾病等。近十年涌现了大量关于Bcl-2家族蛋白生理功能及结构的报道,加深了我们对Bcl-2家族蛋白的作用机制及其病理意义的认识,且在过去几年中,许多针对不同Bcl-2成员的药物已经被开发并进入临床阶段。但Bcl-2家族蛋白功能和结构的复杂性及多样性导致该研究领域仍有大量问题尚待解决。该文总结了目前关于Bcl-2蛋白家族结构和功能的知识,还讨论了Bcl-2蛋白作为有效分子治疗靶点的药理学意义。
Apoptosis is an important biological process that plays a key role in the regulation of cell fate and homeostasis. The B-cell lymphoma-2(Bcl-2) family proteins are important regulators of the apoptotic pathway, and their dysfunction is associated with a variety of diseases, including cancer, neurodegenerative and autoimmune diseases. In the past decade, a large number of research work on the physiological functions and atomic structures of Bcl-2 family proteins have been reported, which has deepened our understanding of the molecular mechanism and pathological significance of Bcl-2 family proteins. Recently, new drugs targeting different Bcl-2 proteins have been developed and used in clinics or tested in clinical trials. However, the complexity and diversity in functions and structures of Bcl-2 family have left many unsolved problems. This article summarizes current knowledge of the structure and function of Bcl-2 family proteins and discusses the pharmacological significance of Bcl-2 proteins as effective therapeutic targets.
作者
冯健愉
朱玉山
陈佺
林家凌
Feng Jianyu;Zhu Yushan;Chen Quan;Lin Jialing(College of Life Sciences,Nankai University,Tianjin 300074,China;Department of Biochemistry and Molecular Biology,University of Oklahoma Health Sciences Center,Oklahoma 73126,USA)
出处
《中国细胞生物学学报》
CAS
CSCD
2019年第8期1477-1489,共13页
Chinese Journal of Cell Biology
基金
美国国立卫生研究院课题(批准号:R01GM062964)
俄克拉荷马州科学技术促进中心课题(批准号:HR16-026)
美国国立卫生研究院课题国家普通医学科学研究所的机构发展奖(批准号:P20GM103640)资助的课题~~
