摘要
目的X射线摄影微钙化征象在乳腺癌筛查、术前对病灶范围的评估以及治疗后的监测均有一定价值。目前,鲜见文献报道确定微钙化特征是否能够在浸润性乳腺癌中预测分子亚型。本研究通过总结HER2阳性乳腺癌X射线摄影表现的微钙化特点,研究其与其他分型浸润性乳腺癌的差异,指导临床通过X射线摄影表现预测乳腺癌分子分型。方法收集大连医科大学附属大连市中心医院2015-01-01-2017-12-31行手术治疗的浸润性乳腺癌且术前均行X射线摄影检查的患者225例,分为HER2阳性组61例和非HER2阳性组164例。对2组患者的X射线摄影微钙化特征进行记录、总结,包括是否存在微钙化、微钙化是否清晰、是局限性微钙化还是弥漫性微钙化,对比2组患者X射线摄影微钙化的特点。结果HER2阳性组X射线摄影特征与非HER2阳性组存在差异,HER2阳性组微钙化发生率为85.2%,高于非HER2阳性组的50.6%,差异有统计学意义,χ^2=18.088,P<0.001;HER2阳性组微钙化清晰比为88.0%,高于非HER2阳性组的37.3%,差异有统计学意义,χ^2=35.552,P<0.001;HER2阳性组弥漫性微钙化比例为52.0%,高于非HER2阳性组的9.6%,差异有统计学意义,χ^2=29.426,P<0.001。结论HER2阳性与非HER2阳性乳腺癌X射线摄影检查的微钙化特点具有一定的差异,HER2阳性浸润性乳腺癌微钙化更为常见,且其微钙化清晰的比例高、范围更广,对临床通过X射线摄影检查的微钙化特征预测浸润性乳腺癌分子分型有一定指导意义。
OBJECTIVE The characterization of x-ray mammographic microcalcifications are valuable in breast cancer screening and preoperative evaluation of disease extent as well as surveillance after treatment.There is no literature report on whether calcification characteristics can predict molecular subtypes in invasive breast cancer.We summarized the features of mammographic microcalcifications in HER2 positive breast cancer and investigated its difference with other molecular subtypes of invasive breast cancer in order to guide the clinical prediction of breast cancer molecular type by x-ray imaging.METHODS A total of 225 patients,from January 1,2015 to December 31,2017,who have undergone surgery and undergone x-ray examination preoperatively in Dalian Municipal Central Hospital Affiliated of Dalian Medical University were selected for research.They were divided into HER2 positive group(n=61)and non-HER2 positive group(n=164).The features of mammographic microcalcifications in the two groups were recorded and summarized,including if the microcalcification was present,whether the microcalcification was clear,localized or diffuse microcalcification.The differences in features of mammographic microcalcifications between the two groups were analyzed.RESULTS The x-ray features of HER2 positive group were different from those of the non-HER2 positive group.The incidence of microcalcification was higher in HER2 positive group than that in the non-HER2 positive group(85.2%vs 50.6%,χ^2=18.088,P<0.001).Microcalcification was clearer in HER2 positive group than that in the non-HER2 positive group(88.0%vs 37.3%,χ^2=35.552,P<0.001).The proportion of diffuse microcalcification was higher in HER2 positive group than that in the non-HER2 positive group(52.0%vs 9.6%,χ^2=29.426,P<0.001).CONCLUSIONS The x-ray microcalcification characteristics of HER2 positive and non-HER2 positive breast cancer are different.The microcalcification of HER2-positive breast cancer is more common,and more clear,and the range is wider.The finding may help
作者
姜雪
祖国
姜力群
郭文斌
JIANG Xue;ZU Guo;JIANG Li-qun;GUO Wen-bin(Dalian Municipal Central Hospital Affiliated of Dalian Medical University,Dalian 116033,P.R.China;Graduate School,Dalian Medical University,Dalian 116044 R.China)
出处
《中华肿瘤防治杂志》
CAS
北大核心
2019年第17期1280-1283,共4页
Chinese Journal of Cancer Prevention and Treatment
关键词
乳腺癌
X射线摄影钙化
分子分型
HER2阳性
breast cancer
x-ray mammographic microcalcification
molecular subtype
HER2 positive
