摘要
以二醋酸碘苯(PhI(OAc)2)为温和的氧化剂,探索了α,β-不饱和酰腙的无金属氧化环化反应,在25℃下以高达92%的产率得到了一系列1,3,5-三取代N-酰基吡唑类化合物.通过1HNMR和13 CNMR对目标产物的结构进行了表征.结果表明,该方法具有反应条件温和、反应时间短、易于操作以及反应产率高等优点,为N-酰基吡唑类化合物的合成提供了一种简便有效的方法.
A series of 1,3,5-trisubstituted N-acyl pyrazoles were synthesized by using iodobenzene diacetate(PhI(OAc)2)as a mild oxidant through metal-free oxidative cyclization ofα,β-unsaturated acylhydrazones.The corresponding products were obtained with up to 92%yields at 25℃.The structures of 1,3,5-trisubstituted N-acyl pyrazoles were characterized by 1HNMR and 13 CNMR spectrum.The method has the advantages of mild reaction condition,short reaction time,simple operation and high reaction yields.It provides a simple and effective method for the synthesis of N-acyl pyrazoles.
作者
王克虎
张学清
柴丽
黄丹凤
WANG Ke-hu;ZHANG Xue-qing;CHAI Li;HUANG Dan-feng(College of Chemistry and Chemical Engineering,Northwest Normal University,Lanzhou 730070,Gansu,China)
出处
《西北师范大学学报（自然科学版）》
CAS
北大核心
2019年第6期57-61,共5页
Journal of Northwest Normal University(Natural Science)
基金
国家自然科学基金资助项目(21861033,21462037)
