摘要
目的对比分析术前新辅助化疗与腔内放疗在局部晚期宫颈鳞癌治疗中的疗效。方法采用回顾性研究方法,选取2012年3月至2017年7月徐州医科大学附属连云港医院收治的IB2、IIA2期宫颈鳞癌患者60例,根据术前治疗方法的不同,将其分为术前新辅助化疗组和术前腔内放疗组,每组各30例。两组均行根治性子宫切除术与盆腔淋巴结清扫术。比较两组患者的临床疗效、手术情况、不良反应发生情况及1年生存率。结果术前化疗组与术前放疗组患者的临床有效率分别为90.00%和63.33%,差异具有统计学意义(P<0.05);术前化疗组患者的手术时间与术中出血量分别为(4.63±0.92)h、(330.00±157.90)ml,均少于术前放疗组的(5.41±0.76)h、(413.33±138.30)ml,差异具有统计学意义(P<0.05);术前化疗组与术前放疗组患者的手术并发症(10.0%vs.16.67%)及不良反应发生率(6.67%vs.23.33%)、生存率(90.0%vs.96.7%)比较,差异均无统计学意义(P>0.05)。结论术前新辅助化疗较腔内放疗更能减少局部晚期宫颈鳞癌患者的手术时间及出血量,提高近期疗效,应用价值明显。
Objective Comparative analysis of preoperative neoadjuvant chemotherapy and intracavitary radiotherapy in the treatment of locally advanced cervical squamous cell carcinoma.Methods A retrospective study was conducted to select 60 patients with squamous squamous cell carcinoma of IB2 and IIA who were admitted to Lianyungang Hospital affiliated to Xuzhou Medical University from March 2012 to July 2017.According to different preoperative treatment methods,they were divided into preoperative new patients.The adjuvant chemotherapy group and the preoperative intracavitary radiotherapy group,30 cases in each group.Radical hysterectomy and pelvic lymphadenectomy were performed in both groups.Compare the clinical efficacy,surgical status,adverse reactions and 1-year survival rate of the two groups of patients.Results The clinical effective rate of the preoperative chemotherapy group and the preoperative radiotherapy group were 90.00%and 63.33%,respectively,and the difference was statistically significant(P<0.05).The operation time and intraoperative blood loss of the preoperative chemotherapy group were(4.63±0.92)h,(330.00±157.90)ml,which were less than(5.41±0.76)h and(413.33±138.30)ml in the preoperative radiotherapy group,the difference was statistically significant(P<0.05);preoperative chemotherapy group and There were no significant differences in the operative complications(10.0%vs 16.67%)and the incidence of adverse reactions(6.67%vs.23.33%)and survival rate(90.0%vs.96.7%)in the preoperative radiotherapy group(P>0.05).Conclusion Preoperative neoadjuvant chemotherapy can reduce the operation time and blood loss of locally advanced cervical squamous cell carcinoma compared with intracavitary radiotherapy,and improve the short-term curative effect.
作者
张艳丽
冯文
胡东东
ZHANG Yan-li;FENG Wen;HU Dong-dong(Department of Obstetrics and Gynecology,Lianyungang Hospital,Xuzhou Medical University,Lianyungang Jiangsu 222002,China)
出处
《临床和实验医学杂志》
2019年第19期2115-2118,共4页
Journal of Clinical and Experimental Medicine
基金
江苏省卫健委资助项目(编号:F201669)
关键词
宫颈鳞癌
新辅助化疗
腔内放疗
Cervical squamous cell carcinoma
Neoadjuvant chemotherapy
Intracavitary radiothera
