摘要
外泌体是细胞膜衍生出的一类通过在细胞间传递RNA和蛋白质来调控细胞间通讯的小囊泡。研究发现,当细胞受到压力释放外泌体后,可加重各种病理变化的进程,如病毒的感染过程。而外泌体microRNA(miRNA)在病毒感染及产生炎症时又起着调控作用。流感病毒感染是引起流行性感冒及病毒性肺炎的重要原因,感染机制复杂且尚未得到全面阐述。流感病毒可入侵人体呼吸道,多引发肺部炎症加重肺部损伤,甚至导致肺衰竭。本文总结目前研究进展,重点阐述了外泌体在流感病毒感染中的作用机制及对肺部炎症的影响,为后续研究提供了相关思路及理论指导,以期为流感病毒引起的疾病带来新的有效诊疗方法。
Exosomes are small vesicles derived from cell membranes that regulate intercellular communication by transmitting RNA and proteins between cells. Studies have shown that if cells are subjected to pressure to release exosomes,the progression of various pathological changes can be aggravated,such as the infection process of a virus. The microRNAs(miRNAs)in the exosome have a regulatory role in viral infection and inflammation. Influenza virus infection is an important cause of influenza and viral pneumonia. The infection mechanism is complex and has not been fully elaborated. Influenza viruses can invade the human respiratory tract,causing lung inflammation to aggravate lung damage and even lead to lung failure.This paper summarizes the current research progress,highlights the mechanism of action of exosomes in influenza virus infection and its impact on lung inflammation,to provide relevant ideas and theoretical guidance for follow-up research,with a view to bringing new effective treatment methods for diseases caused by influenza viruses.
作者
袁娉
廖灿
卢芳国
张波
李玲
YUAN Ping;LIAO Can;LU Fangguo;ZHANG Bo;LI Ling(College of Integration of Traditional Chinese and Western Medicine,Hunan University of Chinese Medicine,Changsha A10208,China;College of Traditional Chinese Medicine,Hunan University of Chinese Medicine,Changsha 410208,China;Medical College,Hunan University of Chinese Medicine,Changsha 410208,China)
出处
《病毒学报》
CAS
CSCD
北大核心
2019年第5期831-835,共5页
Chinese Journal of Virology
基金
国家自然基金课题(项目号:81973670,81503445,81774126)
湖南省自然科学基金项目(项目号:2016JJ2095)
湖南中医药大学大学生研究性学习与创新性实验项目(项目号:2017-06,2018-01,2018-31)
湖南省高校科技创新团队《感染性疾病中医药防治研究》资助项目(项目号:15)~~
