摘要
目的:探讨自体骨髓干细胞对胆汁性肝硬化的疗效及对血清甲胎蛋白(AFP)、糖类抗原125(CA125)及肝纤维化的的影响。方法:将我院2016年1月至2018年1月收治的95例胆汁性肝硬化患者通过简单随机数字表法将所有受试者分为观察组50例和对照组45例,对照组给予常规治疗,包括口服熊去氧胆酸胶囊、多烯磷酯酰胆碱胶囊、复方甘草酸苷片等,观察组在对照组治疗基础上,连续用药4周后实施自体骨髓干细胞移植。比较两组临床疗效、血清AFP、CA125、肝功能指标、肝纤维化指标及不良反应。结果:治疗后,观察组临床疗效总有效率明显高于对照组[84.00%(42/50)vs62.22%(28/45)](P<0.05);观察组血清AFP、CA125明显低于对照组[(4.42±0.75)ng/mL vs(5.88±0.91)ng/mL,(61.09±8.31)U/mL vs(75.63±10.51)U/mL](P<0.05);观察组天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)、总胆红素(TBil)、碱性磷酸酶(ALP)、谷氨酰转肽酶(GGT)、和肝纤维指标透明质酸(HA)、Ⅲ型前胶原(PCⅢ)、层粘蛋白(LN)均明显低于对照组(P<0.05);两组不良反应总发生比较差异无统计学意义(P>0.05)。结论:在胆汁性肝硬化患者中使用自体骨髓干细胞移植效果显著,可有效改善肝功能、肝纤维化,降低血清AFP、CA125的表达,且安全性高,值得应用推广。
Objective:To study the curative efficacy of autologous bone marrow stem cells in treatment of biliary cirrhosis and effects on serum alpha fetoprotein(AFP),carbohydrate antigen 125(CA125)and liver fibrosis.Methods:95 patients of biliary cirrhosis who received therapy from January 2016 to January 2018 in our hospital were were divided into the 50 cases of the observation group and the 45 cases of the control group by the simlpe random number table,the control group was given routine treatment,including oral ursodeoxycholic acid capsules,polyene phosphatidylcholine capsules,Compound Glycyrrhizin tablets,etc,the observation group was treated with autologous bone marrow stem cell transplantation for after treatment 4 weeks on the basis of the control group.The clinical efficacy,serum AFP,CA125,liver function indexes,liver fibrosis indexes and adverse reactions were compared between the two groups.Results:After treatment,the total effective rate in the observation group was significantly higher than those in the control group[84.00%(42/50)vs62.22%(28/45)](P<0.05);the serum AFP and CA125 levels in observation group were significantly lower than those in control group[(4.42±0.75)ng/ml vs(5.88±0.91)ng/ml,(61.09±8.31)U/ml vs(75.63±10.51)U/ml](P<0.05);the indexes of aspartate aminotransferase(AST),alanine aminotransferase(ALT),total bilirubin(TBil),alkaline phosphatase(ALP),glutamyltransferase(GGT)and the indexes of liver fibrosis such as hyaluronic acid(HA),type III procollagen(PCIII),laminin(LN)in the observation group were significantly lower than those in the control group(P<0.05);there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Autologous bone marrow stem cells is well for biliary cirrhosi,which can effectivelyimprove liver function,liver fibrosis,reduce the expression of serum AFP and CA125 levels,and has high safety,it's worth for popularizing.
作者
朱疆依
朱玉侠
梅琳
冯波
郭长存
ZHU Jiangyi(First Affiliated Hospital of Air Force Medical University,Shaanxi Xi'an 710032,China)
出处
《河北医学》
CAS
2019年第9期1418-1422,共5页
Hebei Medicine
基金
陕西省社会发展重点项目,(编号:2018ZDXM-SF-053)
关键词
胆汁性肝硬化
自体骨髓干细胞
甲胎蛋白
糖类抗原125
肝纤维化
Biliary cirrhosis
Autologous bone marrow stem cells
Alpha fetoprotein
Carbohydrate antigen 125
Liver fibrosis
