摘要
心肌梗死等缺血性疾病均可导致心肌纤维化。干细胞疗法可用于修复受损的心脏组织,促进微血管形成,减少瘢痕形成,抑制心肌纤维化。但干细胞归巢、存活、移植效率尚待提升。现总结了系列增效措施:优化干细胞(干预基因重组、预处理干细胞等)、提高靶向性、改善归巢微环境等。干细胞疗法可从“种子”“播种”“土壤”等环节提高干细胞的归巢、移植效率。
Ischemic diseases such as myocardial infarction can lead to myocardial fibrosis.Stem cell therapy can be used to repair damaged heart tissue,promote microangiogenesis,reduce scar formation and inhibit myocardial fibrosis.However,the efficiency of homing,survival and transplantation of stem cells needs to be improved.This paper summarizes a series of synergistic measures:optimizing stem cells(intervening gene recombination,pretreatment of stem cells,etc.),improving targeting,improving homing microenvironment,etc.Stem cell therapy can improve the efficiency of homing and transplanting stem cells from the links of“seed”“sowing”and“soil”.
作者
韦余
胡科
温钞麟
邓玮
WEI Yu;HU Ke;WEN Chaolin;DENG Wei(Department of Gerontology,The Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China)
出处
《心血管病学进展》
CAS
2019年第5期774-777,共4页
Advances in Cardiovascular Diseases
基金
重庆市科委2015年基础与前沿研究计划一般项目(cstc2015jcyjA10074)
重庆市卫计委2015年医学科研计划项目(2015MSXM019)
重庆市教委高校人文社科项目(17SKG022)
国家留学基金2016年度资助(201608500012)
社区教育与老年教育融合发展战略研究(SJ2018-001)
关键词
心肌纤维化
干细胞
提高
Myocardial fibrosis
Stem cells
Improvement
