摘要
恶性肿瘤是严重威胁人类健康的重大慢性病,如何有效地控制以及治愈肿瘤是当今医学领域中亟待解决的首要问题之一。目前手术以及放疗化疗仍是其主要治疗方式,其中放化疗带来的毒副作用不容小觑。因此寻找低毒高效并且对肿瘤细胞具有靶向性的新型抗肿瘤药物具有重要的现实意义。随着肿瘤发病率的不断升高,中药抗肿瘤作用日益成为研究热点,雷公藤甲素是一种来源于雷公藤的天然二萜类活性成分,作为雷公藤的高活性成分之一,具有抗炎、免疫抑制、抗肿瘤等多重作用。大量的体内外研究证实其对多种癌症具有良好的抗肿瘤活性,通过抑制肿瘤细胞增殖、诱导肿瘤细胞凋亡、诱导肿瘤细胞自噬、阻滞肿瘤细胞周期、抑制肿瘤细胞迁移、侵袭和转移、逆转肿瘤多药耐药、介导肿瘤免疫和抑制肿瘤血管生成等方式进而发挥抗肿瘤作用。该文在文献报道的基础上,对雷公藤甲素的抗肿瘤作用及其机制进行综述,并针对目前有关雷公藤甲素的联合应用现状做分析,以促进雷公藤甲素研究的开展及临床上更好的应用。
Tumors are major chronic diseases and seriously threaten human health all over the world.How to effectively control and cure tumors is one of the most pivotal problems in the medical field.At present,surgery,radiotherapy and chemotherapy are still the main treatment methods.However,the side effects of radiotherapy and chemotherapy cannot be underestimated.Therefore,it is of great practical significance to find new anti-cancer drugs with low toxicity,high efficiency and targeting to cancer cells.With the increasing incidence of tumor,the anti-tumor effect of traditional Chinese medicine has increasingly become a research hotspot.Triptolide,which is a natural diterpenoid active ingredient derived from of Tripterygium wilfordii,as one of the highly active components,has anti-inflam-matory,immunosuppressive,anti-tumor and other multiple effects.A large number of studies have confirmed that it has good anti-tumor activity against various tumors in vivo and in vitro.It can play an anti-tumor role by inhibiting the proliferation of cancer cells,in-ducing apoptosis of cancer cells,inducing autophagy of cancer cells,blocking the cell cycle,inhibiting the migration,invasion and metastasis of cancer cells,reversing multidrug resistance,mediating tumor immunity and inhibiting angiogenesis.On the basis of literatures,this paper reviews the anti-tumor effect and mechanism of triptolide,and analyzes the current situation of triptolide combined with other chemotherapy drugs,in order to promote deep research and better clinical application about triptolide.
作者
石金凤
罗尧尧
李佳鑫
罗锐锋
陈梁
李杰
章津铭
傅超美
SHI Jin-feng;LUO Yao-yao;LI Jia-xin;LUO Rui-feng;CHEN Liang;LI Jie;ZHANG Jin-ming;FU Chao-mei(Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine,Key Laboratory of Systematic Research,Development and Utilization of Chinese Medicine Resources in Sichuan Province-State Key Laboratory Breeding Base Co-founded by Sichuan Province and MOST,College of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2019年第16期3391-3398,共8页
China Journal of Chinese Materia Medica
基金
国家自然科学基金青年基金项目(81703718)
2018—2020年度中华中医药学会青年人才托举工程项目(QNRC1-01)
四川省杰出青年科技人才项目(2019JDJQ0049)
中国博士后科学基金第61批面上项目(2017M612930)
关键词
雷公藤甲素
抗肿瘤
作用机制
联合应用
triptolide
anti-tumor effects
mechanism
combined application
