摘要
目的调查分析转化生长因子β诱导基因(TGFBI)基因突变在海南省糖尿病视网膜病变患者中的发生情况。方法选择2013年8月至2018年2月在海南医学院第一附属医院眼科就诊的海南省糖尿病视网膜病变患者78例作为观察组,同期选择本省非糖尿病视网膜病变患者68例作为对照组,两组患者均进行全血组织TGFBI基因突变检测,记录患者的临床特征并进行相关性分析。结果观察组患者的TGFBI基因突变率为10.25%,明显高于对照组的1.47%,差异有统计学意义(P<0.05);8例TGFBI基因突变患者中,-51G>A 3例,-26A>G 3例,310G>A 1例,895G>T 1例;Pearson相关分析结果显示,海南省糖尿病视网膜病变患者的TGFBI基因突变与最佳矫正视力、视网膜厚度、眼压均呈正相关性(P<0.05)。结论TGFBI基因突变在海南省糖尿病视网膜病变患者中比较常见,与患者的临床特征显著相关。
Objective To investigate and analysis the occurrence of transforming growth factor-βinduced gene(TGFBI)gene mutation in diabetic retinopathy in Hainan Province.Methods A total of 78 patients with diabetic retinopathy,who admitted to Department of Ophthalmology,the First Affiliated Hospital of Hainan Medical College from August 2013 to February 2018,were selected as the observation group.During the same period,68 patients with non-diabetic retinopathy in Hainan Province were selected as the control group.The blood tissue TGFBI gene mutation detection,the clinical characteristics of patients were recorded and analyzed.Results The TGFBI gene mutation rate in the observation group was 10.25%,which was significantly higher than 1.47%in the control group(P<0.05).In the 8 patients with TGFBI gene mutation,there were three patients of-51G>A,three patients of-26A>G,one patient of 310 G>A,and one patient of 895G>T.Pearson correlation analysis showed that TGFBI gene mutations in patients with diabetic retinopathy in Hainan were positively correlated with best corrected visual acuity,retinal thickness and intraocular pressure(P<0.05).Conclusion TGFBII gene mutation is more common in diabetic retinopathy in Hainan Province,which is significantly associated with clinical features.
作者
唐平
王玲
陈执
吕博琦
李蒙恩
TANG Ping;WANG Ling;CHEN Zhi;LV Bo-qi;LI Meng-en(Department of Ophthalmology,the First Affiliated Hospital of Hainan Medical University,Haikou 570102,Hainan,CHINA;Hainan Guoai Myopia Lasik Center,Haikou 570208,Hainan,CHINA)
出处
《海南医学》
CAS
2019年第16期2117-2120,共4页
Hainan Medical Journal
基金
海南省卫生计生科研项目(编号：15A200058)
关键词
海南省
转化生长因子β诱导基因
基因突变
糖尿病视网膜病变
Hainan province
Transforming growth factor beta-inducible(TGFBI)gene
Gene mutation
Diabetic retinopathy
