摘要
目的观察老年人群中不同诊断切点(≥10μmol/L;≥15μmol/L;≥20μmol/L)高同型半胱氨酸血症(hyperhomocystinemia,HHcy)患病率及其临床特征。方法选取5976例65岁以上老年人为研究对象,按不同诊断切点分为四组,分析不同同型半胱氨酸(homocysteine,Hcy)水平与肾功能、高血压等的关系。结果(1)HHcy≥10、15、20μmol/L患病率分别为84.96%、41.62%、18.66%。(2)Hcy影响因素中,年龄、肌酐、尿酸不受诊断切点的影响。(3)单因素回归分析显示,血清Hcy水平升高与高尿酸血症、肾功能不全、高血压显著相关,但进一步校正血尿酸、肌酐后,与高血压关系均不再相关(P>0.05)。结论HHcy患病率受诊断切点影响明显,肾功能是影响血浆Hcy水平的主要因素,血浆Hcy水平升高与高血压无独立相关性。
Objective To investigate the prevalence and clinical characteristics of hyperhomocysteinemia(HHcy)at various diagnostic cut-off thresholds(≥10μmol/L,≥15μmol/L,≥20μmol/L)in the elderly population.Methods 5976 elderly people over 65 years old were divided into four groups according to the above mentioned three diagnostic cut-off points.The relationships of various homocysteine(Hcy)levels with renal function and hypertension were analyzed.Results(1)The prevalence of HHcy>10,15 and 20 umol/L was 84.96%,41.62%and 18.66%,respectively.(2)Age,serum creatinine and uric acid were associated with HHcy regardless of the diagnostic cut-off point.(3)Univariate analysis showed that higher HHcy was related with hyperuricemia,renal insufficiency and hypertension.After further adjustment for serum uric acid and creatinine,however,the association between HHcy and hypertension became non-significant(P>0.05).Conclusions The prevalence of HHcy varied substantially across the diagnostic cut-off thresholds.Renal function was a major determinant of HHcy.HHcy was not independently associated with hypertension.
作者
谭琴
王继光
李燕
王点
陈怡
郭芊卉
TAN Qin;WANG Jiguang;LI Yan(The Shanghai Institute of Hypertension,Ruijin Hospital,Shanghai 200025,China)
出处
《心脑血管病防治》
2019年第4期292-295,共4页
CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT
