摘要
目的 调查 6 8例临床使用庆大霉素患者所致听力损伤的发生率及特点 .方法 采用纯音测听和脑干诱发电位检查 ,并随访 6 8例患者使用庆大霉素前后听力变化 .结果 平均使用庆大霉素 (112 0± 310 ) m g,随访 2 7～ 76 (平均 4 3±9) d,用药前纯音测听平均阈值为 (13.3± 7.3) d B HL,停药时平均阈值为 (13.8± 8.9) d B HL,随访纯音测听平均阈值为(14 .2± 9.8) d B HL ,发生听力损伤 18例 (2 6 % ) ,多数表现在高频区 ,且有 4例为单耳损伤 . 1例有主观症状者治疗后耳聋减轻 .结论 临床使用庆大霉素 6 8例的听力损伤发生率为 2 6 .5 % ,多在高频区 ,治疗期间及用药应了解听力情况和变化 。
AIM To investigate the occurrence of gentamycin induced hearing loss in clinical practice. METHODS 68 patients were checked and followed up by audiometer and acoustic brainstem response before and after taking gentamycin. RESULTS The mean gentamycin dosage was 1120 mg, and the follow up lasted 27～76 (mean 43±9) days. The mean hearing threshold before the administration was (13.3±7.3)dB HL, that after the administration was (13.8±8.9) dB HL, and that at follow up was (14.2±9.8) dB HL. 18 patients suffered hearing loss mostly in high frequency areas, and four with unilateral ears. One patient with subjective symptoms got hearing loss remission after timely treatment. CONCLUSION Audiogram should be performed before the use of gentamycin, and timely treatment and preventive measures are very important.
出处
《第四军医大学学报》
北大核心
2002年第19期1793-1795,共3页
Journal of the Fourth Military Medical University
关键词
庆大霉素中毒
耳毒性
随访研究
gentamicin/poisining
ototoxicity
follow up studies
