摘要
目的 了解庆大霉素 (GM)早期耳中毒后 ,应用谷胱苷肽 (GSH)治疗能否改善听力。方法 选听力正常豚鼠 30只 ,随机分 3组 ,观察组 12只 (肌注GM 10 0mg kg-1·d-1,一旦ABR阈移 10dB以上立即停药观察 ) ,治疗组 12只 (按观察组用药 ,停药 ,停药后再用GSH 5天 ) ,对照组 6只 (仅肌注等量盐水 )。所有动物在用药前后均检测ABR之波Ⅲ反应阈。停药二周后处死作耳蜗铺片。结果 观察组停用GM二周后复查ABR阈移继续增大 (P <0 0 1)。治疗组停用GM二周后无明显阈移 (P >0 0 5 )。对照组则前后无变化。耳蜗毛细胞形态变化与功能变化基本一致。结论 早期GM耳中毒一旦出现ABR阈移即使立即停药听力损害仍将继续加重 ;
Objective To investigate the hearing change after the administration of glutathione(GSH) in the early detection of gentamicin (GM) ototoxicity.Methods 30 guinea pigs were randomly divided into 3 groups,12 in observation group(GM injection was immediately stopped once the wave Ⅲ Threshold shift reached 10 dB HL),12 in treatment group(GM injection was stopped and treatment of GSH was given for 5 days),6 in control group(saline were injected).The threshold of Ⅲ wave of ABR was monitored before and after the injection of drugs.All the animals of cease-GM treatent were sacrificed in 2 weeks later to receive a morphological observation of hair cell.Results Two weeks after cease-GM treatment,the threshold shift was obvious in observation group(P<0.01)while it was not so in the treatment group and the control group(P>0.05).The morphological change was almost the same as that of function Conclusion There was further hearing loss when the abnormal ABR was presented even if the administration of GM had been stopped.GSH could prevent the further hearing loss resulted from GM ototoxicity.
出处
《听力学及言语疾病杂志》
CAS
CSCD
2000年第4期217-218,共2页
Journal of Audiology and Speech Pathology
关键词
谷胱苷肽
庆大霉素
耳毒性
治疗
Gentamicin Ototoxicity Glutathione Treatment
