摘要
目的 了解赖诺普利是否具有改善糖尿病早期肾脏病变的作用 ,并比较几种尿微量蛋白之间的敏感性。方法 将 94例血压正常、尿微量蛋白增高的 2型糖尿病患者随机分为 3组 :①赖诺普利治疗组 (n =34 ) :口服赖诺普利 10mg/d治疗 12周 ;②洛汀新治疗组 (n =31) :口服贝那普利 10mg/d治疗 12周 ;③对照组(n =2 9) :口服维生素C 10 0mg/d 12周。用免疫透射法测定治疗前后尿微量白蛋白 (Alb)、α1 微球蛋白 (α1 MG)、转铁蛋白 (TRF)和免疫球蛋白G(IgG)的变化 ,并进行统计分析。结果 3组在治疗前各种尿微量蛋白阳性率之间无显著差异 ,但尿TRF、IgG增高的比例 (分别为 97.4%,89.8%)明显高于Alb(75 .2 %)和α1 MG(4 7.2 %) (P <0 .0 1) ,尿TRF阳性率还明显高于IgG ;Alb明显高于α1 MG(P <0 .0 5 )。治疗 12周后 ,贝那普利组和赖诺普利组的尿TRF、IgG、Alb和α1 MG水平均较治疗前明显下降 (P <0 .0 1,P <0 .0 5 ,P <0 .0 1,P <0 .0 5 ) ;但两治疗组上述指标之间无明显差别 (P >0 .0 5 ) ;且治疗组的上述尿蛋白水平显著低于同期对照组 (P <0 .0 1)。对照组的尿TRF、IgG和Alb浓度较 12周前明显增加 (P <0 .0 1,P <0 .0 5 ) ,而尿α1 MG变化不大 (P >0 .0 5 )。
Purpose: To observe whether or not Linsinopril can improve the diabetic nephropathy in normotensive type 2 diabetic patients, and compare the sensitivity of serveral protein indexes in urine. Methods: 94 diabetic cases complicated with microproteinuria were divided randomizedly into three groups: 1 Linsinopril treatment group(n = 34): Linsinopril 10 mg was used orally once a day for 12 weeks; 2 Benazepril treatment group(n = 31): Benazepril hydrochloride 10 mg was eaten once a day for 12 weeks; 3 Control group(n = 29): Vitamine C 100 mg was administrated as above. The urinary concentrations of albumin(Alb), α1-microglobulin (α1-MG), transfein (TRF) and immunoglobulin G (IgG) were detected by immunoscenography assay in these three groups before and after therapy, and the results were analyzed statistically. Results: There was no significant difference in 4 urinary indications among these three groups before treatment, but among 94 patients, the postivity of increasing TRF(97.4%) and IgG(89.8%) was higher than that of Alb 75.2% and α1-MG(47.2%) (both P 0.05). The urinary concentration of TRF, IgG and Alb in control group increased significantly than 12 weeks ago, but that of α1-MG didn't change markly. Conclusions: The measurement of urine TRF and IgG were more sensitive than Alb detection alone. Linsinopril improves the diabetic nephropathy through reducing the leakage of urine microprotein, and its influence on diabetic patients complicated with microalbuminuria was silmilar to Benazepril. The diabetic nephropathy after 12 weeks became serious if no ACEI drugs on time.
出处
《复旦学报（医学版）》
EI
CAS
CSCD
北大核心
2002年第6期501-503,506,共4页
Fudan University Journal of Medical Sciences
关键词
赖诺普利
2型糖尿病
尿微量蛋白
Body fluids
Drug therapy
Immunology
Patient treatment
Proteins
Statistical methods
