摘要
研究了2,5-二甲苯酚与1,3-二卤代丙烷及一卤代羧酸酯的O-烷基化反应.2,5-二甲苯酚与1,3-二溴丙烷在NaOH-H<sub>2</sub>O,NaOH-甲苯-DMSO或无水K,CO<sub>3</sub>-丙酮中反应,产物均为1-（2,5-二甲苯氧基）-3-溴丙烷,产率分别为59.8%,64.5%和74.0%.2,5-二甲苯酚与1-溴-3-氯丙烷在无水K<sub>2</sub>CO<sub>3</sub>-丙酮中反应,产物为1-（2,5-二甲苯氧基）-3-氯丙烷,产率为77.5%.上述产物的结构由<sup>1</sup>HNMR和IR数据所确定.2,5-二甲苯酚与一卤代羧酸酯的反应产率在81%以上.
The O-alkylation of 2,5-dimethylphenol with 1,3-dihalogen- propane and some monohalogen carboxylic esters are studied.In NaOH-H_2O, NaOH-toluene-DMSO or anhydrous K_2CO_3-acetone the O-alkylation of 2,5- dimethylphenol with 1,3-dibromopropane give 1-(2,5-dimethyl phenoxyl) -3-bromopropane,the yield is 59.8%,64.5% and 74% respectively.In anhy- drous K_2CO_3-acetone the O-alkylation of 2,5-dimethylphenol with 1-bromo -3-chloropropane give 1-(2,5-dimethyl phenoxyl)-3-chloropropane,the yield is 77.5%.The structures of resultants are mainly elucidated by spectrum methods(IR,~1HNMR).The yield of O-alkylation of 2,5-dimethylphenol with the monohalogen carboxylic esters is above 81%.
出处
《北京师范大学学报（自然科学版）》
CAS
CSCD
1992年第3期379-382,共4页
Journal of Beijing Normal University(Natural Science)
基金
国家自然科学基金
关键词
二甲苯酚
二溴丙烷
O-烷基化
2,5-dimethylphenol
1,3-dibromopropane
1-bromo-3-chlo-ropropane
monohalogen carboxylic ester
O-alkylation
yield
