摘要
细胞内质网应激在畜禽和人类许多的应激反应中普遍存在。细胞在持续内质网应激下诱发未折叠蛋白反应并激活细胞凋亡信号通路。葡萄糖调节蛋白94(GRP94)是内质网应激的标志蛋白,并通过内质网信号途径调控细胞凋亡的发生。本文主要就GRP94及其互作蛋白对内质网应激诱导的肝细胞凋亡的调控机制,及GRP94在肝疾病中如何发挥作用进行综述,以期为畜牧上引起内质网应激的生产条件调控以及临床上与内质网应激相关细胞凋亡的肝病治疗提供参考。
Intracellular endoplasmic reticulum stress(ERS)is ubiquitous in the widespread stress response of livestock,poultry and human beings.Unfolded protein response caused by chronic ERS triggers apoptotic signaling pathways.Glucose-regulated protein 94(GRP94)is a marker protein of ERS,which is essential for the regulation of apoptosis via endoplasmic reticulum signaling.This paper reviews the regulation mechanism of GRP94 and its interaction proteins on hepatocyte apoptosis induced by endoplasmic reticulum stress,and how GRP94 plays a role in liver disease,which will provide a scientific reference for the control on the ERS-inducing production conditions in livestock and the treatment of ERS apoptosis-related liver diseases in clinical medicine.
作者
辛海瑞
郝月
张闯
顾宪红
XIN Hairui;HAO Yue;ZHANG Chuang;GU Xianhong(State Key Laboratory of Animal Nutrition,Institute of Animal Science,Chinese Academyof Agricultural Sciences,Beijing 100193,China)
出处
《畜牧兽医学报》
CAS
CSCD
北大核心
2019年第10期1963-1971,共9页
ACTA VETERINARIA ET ZOOTECHNICA SINICA
基金
国家自然科学基金(31872404
31741116)
中国农业科学院科技创新工程(ASTIP-IAS07)
关键词
葡萄糖调节蛋白94
内质网应激
非折叠蛋白反应
细胞凋亡
肝
glucose-regulated protein 94
endoplasmic reticulum stress
unfolded protein response
apoptosis
liver
