摘要
目的观察对慢性自身免疫性甲状腺炎(AIT)患者联合使用强的松与甲巯咪唑治疗的临床效果。方法选取2017年7月至2019年4月68例AIT患者,将其分为两组。对照组34例使用甲巯咪唑治疗,观察组34例在此基础上联用强的松治疗。比较两组的总有效率、CD4^+、肿瘤坏死因子-α、促甲状腺素、游离三碘甲状腺原氨酸、游离甲状腺素、抗甲状腺过氧化物酶抗体、抗甲状腺球蛋白抗体水平。结果观察组总有效率为94.12%(32/34),对照组为70.59%(24/34),差异有统计学意义(P<0.05)。治疗后,观察组CD4+水平明显高于对照组,肿瘤坏死因子-α、促甲状腺素、游离三碘甲状腺原氨酸、游离甲状腺素、抗甲状腺过氧化物酶抗体、抗甲状腺球蛋白抗体水平明显低于对照组(P<0.05)。结论对AIT患者应用强的松与甲巯咪唑联合治疗可提高治疗效果,改善甲状腺功能及机体免疫,应用效果良好。
Objective To observe the clinical effect of methimazole combined with prednisone on chronic autoimmune thyroiditis. Mehthods Sixty-eight patients with AIT from July 2017 to April 2019 were divided into two groups. Thirty-four patients in the control group were treated with methimazole, and 34 patients in the observation group were treated with prednisone. The total effective rate, CD4^+, TNF-α, thyrotropin, free triiodothyronine, free thyroxine, anti-thyroid peroxidase antibody and anti-thyroglobulin antibody levels were compared between the two groups. Results The total effective rate was 94.12%(32/34) in the observation group and 70.59%(24/34) in the control group, the difference was significant(P<0.05). After treatment, the level of CD4+ in the observation group was significantly higher than that in the control group, and the levels of TNF-α, thyrotropin, free triiodothyronine, free thyroxine, anti-thyroid peroxidase antibody and anti-thyroglobulin antibody in the observation group were significantly lower than those in the control group(P<0.05). Conclusions The combination of prednisone and methimazole in AIT patients can improve the therapeutic effect, improve the thyroid function and immunity, and the application effect is good.
作者
符文耀
陈小晗
王文慧
Fu Wenyao;Chen Xiaohan;Wang Wenhui(Department of Endocrinology,the First People's Hospital of Nanyang,Nanyang 473000,China;Department of Surgery,the First People's Hospital of Nanyang,Nanyang 473000,China;Department of Rheumatology and Immunology,the First People's Hospital of Nanyang,Nanyang 473000,China)
出处
《临床医学》
CAS
2019年第10期97-99,共3页
Clinical Medicine
