摘要
近年来儿童肥胖与维生素D的关系成为研究热点。肥胖儿童体内维生素D水平减低,可能与肥胖者活动减少、接受日晒时间少,皮肤合成维生素D减少、大量维生素D存储于脂肪中导致其生物利用率减低及肝脏维生素D的25-羟化减少有关。减少体脂水平可能有助于恢复正常的维生素D水平。大部分研究结果支持维生素D缺乏状态可能是导致儿童肥胖发生、发展的重要原因之一,然而具体作用机制不明。补充维生素D是否可降低体脂含量从而改善肥胖患儿的预后仍不十分明确。本文就儿童肥胖与维生素D缺乏的关系及其相互影响的可能机制进行综述。
In recent years,the relationship between children obesity and vitamin D has become a research hotspot.Decreased vitamin D levels in obese children may be associated with reduced activity,less exposure to sunlight,reduced skin synthetic vitamin D,reduced bioavailability of vitamin D stored in fat and reduced 25-hydroxylation of vitamin D in liver.Reducing body fat levels may help restore normal vitamin D levels.While the effect of vitamin D deficiency on children obesity is supported by most of the research results and vitamin D deficiency may be one of the important reasons for the occurrence and development of children obesity,the specific mechanism is unclear.Therefore,the relationship between children obesity and vitamin D deficiency needs to be further studied.
作者
李琳珊
苏芊
常波
LI Linshan;SU Qian;CHANG Bo(Department of Endocrinology,Dalian Children's Hospital,Dalian 116012,China)
出处
《大连医科大学学报》
CAS
2019年第5期463-467,共5页
Journal of Dalian Medical University
关键词
儿童
肥胖
维生素D
children
obesity
vitamin D
