摘要
将2型糖尿病患者共80例分为对照组(n=40)和观察组(n=40),对照组患者给予二甲双胍治疗,观察组患者给予沙格列汀联合二甲双胍治疗。两组患者治疗后空腹及餐后2小时血糖、肿瘤坏死因子-α(TNF-a)水平较治疗前均明显降低(P<0.05),可溶性类肿瘤坏死因子细胞凋亡弱诱导剂(sTWEAK)较治疗前明显升高(P<0.05),且对照组与观察组患者治疗后血糖控制指标及炎症因子间差异有显著性(P<0.05),且观察组患者的糖化血红蛋白达标率更高;两组患者治疗后胰岛素抵抗指数(HOMA-IR)水平均明显降低(P<0.05)而胰岛β细胞功能指数(HOMA-β)明显升高(P<0.05),且与对照组患者相比,观察组患者的上述指标变化更显著(P<0.05)。因此,沙格列汀联合二甲双胍可以纠正新诊断2型糖尿病患者炎症因子水平、改善胰岛β细胞功能,有效控制血糖。
Type 2 diabetes patients were divided into two groups according to the treatment method: control group(n=40) and observation group(n=40). The patients in the control group were treated with melbine, while the patients in the observation group were treated with sagliptin and metformin. The results showed that the levels of fasting blood glucose, Tumor Necrosis Factor-α(TNF-a) andsolubleTNF-likeweakinducerofapoptosis(sTWEAK) in the two groups were significantly lower than those before treatment(P<0.05), and significantly higher than those before treatment(P<0.05). Compared with the control group, there were significant differences in blood sugar control indicators and inflammatory factors after treatment in the observation group(P<0.05), and the rate of glycosylated hemoglobin reaching the standard was higher. After treatment, the levels of Homeostasis model assessment(HOMA-IR) in the control group and the observation group decreased significantly(P<0.05), while index of β-cell function in HOMA(HOMA-beta) increased significantly(P<0.05). Compared with the control group, the changes of the above indexes in the observation group were more significant(P<0.05). So Sagliptin combined with metformin can effectively reduce leptin level and improve islet beta cell function in newly diagnosed type 2 diabetes mellitus.
作者
刘曙艳
周雪红
李勇峰
LIU Shuyan;ZHOU Xuehong;LI Yongfeng(Department of Endocrinology,the First Affiliated Hospital of Henan Polytechnic University,Jiaozuo Second People's Hospital,Jiaozuo 454000,Henan,China)
出处
《中南医学科学杂志》
CAS
2019年第5期496-498,541,共4页
Medical Science Journal of Central South China
基金
河南省高校基本科研(项目编号:NSFRF170706)
关键词
沙格列汀
2型糖尿病
炎症因子
Β细胞功能
胰岛素抵抗
saglitine
metformin
type 2 diabetes mellitus
leptin
beta cell function
insulin resistance
