摘要
糖尿病慢性并发症是糖尿病患者致死致残的主要原因,这些并发症的发病机制较为复杂,可能与氧化应激,多元醇通路,蛋白质非酶糖激化,蛋白激酶C等通路相关,在这些通路中可能存在控制糖尿病慢性并发症发生的治疗靶点。以中医络病理论为基础,根据糖尿病"久病入络"的特点,总结出络脉瘀阻、络脉空虚、络脉损伤(毒邪损络)是糖尿病慢性并发症的主要病机,以"络以通为用"的治疗原则,寻求中医药防治糖尿病慢性并发症的作用靶点,为中医药临床研究、新药研发和改进临床用药的效果提供客观依据。
Chronic complications of diabetes mellitus are the main cause of death and disability in diabetic patients. The pathogenesis of these complications is complex. They may be related to oxidative stress, polyol pathway, protein non-enzymatic glycosylation and protein kinase C pathways. Therapeutic targets may exist in these pathways to control the occurrence of chronic complications of diabetes. Based on the theory of collateral diseases of traditional Chinese medicine and according to the characteristics o f diabetes m ellitus, the main pathogenesis of chronic complications of diabetes mellitus is summarized as collateral stasis, collateral emptiness and collateral damage (toxic pathogens damaging collaterals). The therapeutic principle of “collaterals are used to dredge collaterals” is adopted to seek the target of Chinese medicine in preventing and treating chronic complications of diabetes mellitus, which is facing the clinical research, development and improvement of new drugs of traditional Chinese medicine.
作者
李品
臧凝子
李小娟
宫成军
LI Pin;ZANG Ningzi;LI Xiaojuan;GONG Chengjun(K Department of Endocrine, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine,Shenyang 110032, China)
出处
《长春中医药大学学报》
2019年第5期820-823,共4页
Journal of Changchun University of Chinese Medicine
基金
辽宁省中医药临床学(专)科能力建设项目(2018-125)
辽宁省科学计划项目面上项目(2015020390)
关键词
络病理论
糖尿病慢性并发症
靶点
collateral disease theory
chronic complications of diabetes mellitus
target
