摘要
目的了解内蒙古自治区健康人群麻疹抗体水平,制定针对性措施,有效控制麻疹。方法于2017年在内蒙古自治区采用分层随机抽样的方法抽取2个位于东部的盟市(赤峰、通辽),2个位于西部的盟市(呼和浩特、乌海),共1 372人作为研究对象,采用酶联免疫吸附试验(ELISA)方法进行麻疹IgG抗体水平监测。结果1 372份样本中,抗体阳性率为90.96%(1 248/1 372),抗体保护率为59.84%(821/1 372),抗体几何平均滴度(GMC)为1 321.28 IU/ml。东部地区与西部地区抗体阳性率差异有统计学意义(91.04%vs 80.92%,P<0.05)。各年龄组之间抗体阳性率(60.87%~96.67%)、保护率(49.18%~68.70%)差异均有统计学意义(P<0.05)。结论应加强对麻疹免疫薄弱地区和易感人群的麻疹监测,制定含麻疹类疫苗(MCV)补种策略,以达到完全消除麻疹的目的。
Objective To study the antibody levels of measles in healthy population in Inner Mongolia Autonomous Region of China. Methods In 2017,two east Inner Mongolian cities(Chifeng,Tongliao)and two west cities(Huhhot and Wuhai)were selected by stratified method for this study from the Inner Mongolia Autonomous Region of China.A total of 1 372people were recruited as research objects,and the enzyme-linked immunosorbent assay(ELISA)was used to detect the measles IgG antibody levels. Results Among the 1 372samples,the antibody positive rate was 90.96%,the protection rate was 59.84%,and the geometric mean concentration (GMC)was 1 321.28IU/ml.There was a significant difference in antibody positive rates between the eastern and western regions(91.04%vs 80.92%,P<0.05).There were significant differences in positive rate(60.87%~96.67%)and protection rate (49.18%~68.70%)among all age groups(P< 0.05). Conclusions Corresponding measures should be taken to strengthen the surveillance and prevention of measles in areas with weak measles immunity and susceptible population.
作者
滕跃
王文瑞
田晓灵
郭雨
顾苏仪
TENG Yue;WANG Wen-rui;TIAN Xiao-ling;GUO Yu;GU Su-yi(Baotou Medical College,Inner Mongolia Autonomous Region,Baotou,Inner Mongolia 014040,China)
出处
《中国病毒病杂志》
CAS
2019年第5期357-360,共4页
Chinese Journal of Viral Diseases
基金
内蒙古2016年度“草原英才”工程([2016]40号)
加强西部地区麻疹监测项目(CHN-13-EP1-005476)
关键词
麻疹
抗体
健康人群
监测
酶联免疫吸附试验
Measles
Antibody
Healthy population
Surveillance
Enzyme-linked immunosorbent assay
