摘要
目的:探讨天麻钩藤饮联合丁苯酞治疗急性脑梗死(ACI)的临床效果。方法:选取2018年6月至2019年4月六安市中医院收治的ACI患者50例作为研究对象,按照随机数字表法分为对照组和观察组,每组25例。对照组给予常规治疗,观察组在此基础上给予天麻钩藤饮联合丁苯酞治疗。统计2组患者临床治疗有效率;比较2组患者治疗前后血清丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化酶(GSH-PX)水平、氧化型低密度脂蛋白(ox-LDL)水平变化情况;观察2组患者治疗前后美国国立卫生研究院卒中量表(NIHSS)和改良RarIkin量表(MRS)评分、日常生活活动能力(BI)评分情况;结果:治疗后观察组NIHSS、MRS评分与MDA、ox-LDL水平均显著低于治疗前,且NIHSS、MRS评分与MDA水平均明显低于对照组,差异有统计学意义(P<0.05);治疗后观察组BI评分和SOD、GSH-PX水平均明显高于治疗前与对照组,差异有统计学意义(P<0.05);治疗后观察组临床治疗有效率明显高于对照组,差异有统计学意义(P<0.05)。结论:天麻钩藤饮联合丁苯酞治疗可有效改善ACI患者的临床症状,增强机体清除自由基的能力,减轻氧化刺激反应,减轻脑缺血损伤,提高临床治疗有效率,且疗效优于常规治疗。
Objective: To explore the clinical effect of Tianma Gouteng Decoction combined with butylphthalide in treatment of acute cerebral infarction(ACI). Methods: A total of 50 patients with ACI admitted to Traditional Chinese Hospital of Lu′an from June 2018 to April 2019 were selected as study objects and divided into a control group( n =25)and an observation group( n =25)according to random number table method.The control group was given routine treatment,while the observation group was given Tianma Gouteng Decoction combined with butylphthalide treatment.Clinical total effective rate of the 2 groups was counted;MDA,ox-LDL,SOD,GSH-PX level changes of the 2 groups were compared before and after treatment;NIHSS,MRS,BI scores of the 2 groups were observed before and after treatment. Results: After treatment,the NIHSS,MRS scores,MDA and ox-LDL levels in the observation group were significantly lower than those before treatment,and the NIHSS,MRS scores and MDA levels in the observation group were significantly lower than those in the control group( P <0.05);After treatment,the BI scores and SOD,GSH-PX levels in the observation group were significantly higher than those before treatment and the control group( P <0.05);After treatment,the total clinical efficiency of the observation group was significantly higher than that of the control group( P <0.05). Conclusion: Tianma Gouteng Decoction combined with butylphthalide can effectively improve the clinical symptoms of ACI patients,enhance the ability of scavenging free radicals,reduce oxidative stimulation response,alleviate cerebral ischemia injury,and improve the total clinical effective rate,and the therapeutic effect is better than routine treatment,which is worthy of clinical promotion and application.
作者
聂宗泉
Nie Zongquan(Department of Neurology,Traditional Chinese Hospital of Lu′an,Lu′an 23700,China)
出处
《世界中医药》
CAS
2019年第9期2363-2366,共4页
World Chinese Medicine
基金
安徽省2009年自然科学基金项目(090413266)
关键词
急性脑梗死
天麻钩藤饮
丁苯酞
神经功能
临床疗效
Acute cerebral infarction
Tianma Gouteng Decoction
Butylphthalide
Neurological function
Clinical efficacy
