摘要
目的:探讨生精种玉汤治疗少精弱精性不育的疗效及对精液中Caspase 3和Caspase 8的影响,为其临床诊治提供参考。方法:选取2015年6月至2018年6月惠州市中心人民医院收治的少精弱精性不育患者96例作为研究对象,按照随机数字表法分为对照组和观察组,每组48例。对照组患者给予五子衍宗丸治疗,观察组患者给予生精种玉汤治疗,比较2组患者治疗前后精液各参数以及精液中、精子中Caspase 3和Caspase 8水平变化。结果:与治疗前比较,2组患者精子密度、精子成活率、a级精子活力以及a+b级精子活力等精液各参数均明显升高,精液中Caspase 3、Caspase 8水平和精子中Caspase 3和Caspase 8水平明显降低(均P<0.05),且观察组上述指标改善更为显著(P<0.05)。观察组患者治疗有效率为95. 83%,明显高于对照组的83. 33%,2组比较差异有统计学意义(P<0.05)。结论:生精种玉汤治疗少精弱精性不育患者,可以明显降低精液中Caspase 3和Caspase 8水平,增强精子活力,标本兼治,效果更加显著,值得临床推广使用。
Objective: To explore the effects of Shengjing Zhongyu Decoction on the treatment of oligospermia and asthenospermia infertility and its influence on Caspase 3 and Caspase 8 in semen,and to provide reference for its clinical diagnosis and treatment. Methods: A total of 96 patients with oligospermia and asthenospermia infertility admitted to Huizhou Central People′s Hospital from June 2015 to June 2018 were enrolled in the study.They were divided into a control group and an observation group according to random number method,with 48 cases each.The control group was treated with Wuzi Yanzong Pill.The patients in the observation group were treated with Shengjing Zhongyu Decoction.The parameters of semen and the changes of Caspase 3 and Caspase 8 in semen and sperm were compared before and after treatment. Results: Compared with before treatment,the sperm density,sperm survival rate,a-level sperm activity,a+b-level sperm activity and other semen parameters of the 2 groups were significantly increased,and the levels of caspase-3 and caspase-8 in semen and sperm were significantly decreased,and the improvement of the above indicators was more significant in the observation group( P <0.05).The effective rate of treatment in the observation group was 95.83%,which was significantly higher than 83.33% in the control group.The difference was statistically significant( P <0.05). Conclusion: Shengjing Zhongyu Decoction can significantly reduce the levels of Caspase 3 and Caspase 8 in semen,enhance the sperm motility,and treat the symptoms more effectively.It is worthy of clinical promotion.
作者
李亦聪
潘恩山
陈翠萍
Li Yicong;Pan Enshan;Chen Cuiping(Department of Traditional Chinese Medicine,Huizhou Central People′s Hospital,Huizhou 516001,China;Department of Urology, Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Southern Medical University,Guangzhou 510000,China)
出处
《世界中医药》
CAS
2019年第9期2359-2362,2366,共5页
World Chinese Medicine
基金
广东省中医药局“建设中医药强省”课题(20152085)
