摘要
目的探讨芪龙定喘膏滋联合自血穴位注射治疗慢性阻塞性肺疾病(COPD)缓解期的临床疗效及对免疫功能的影响。方法选取2016年1月至2018年1月于秦皇岛市中医医院就诊的60例COPD缓解期患者为研究对象,按照治疗方法不同分为对照组和观察组,各30例。对照组给予沙美特罗替卡松粉吸入剂,观察组在对照组的基础上加用芪龙定喘膏滋联合自血穴位注射,两组患者疗程均为30 d。比较两组患者治疗后的临床疗效,比较治疗前后肺功能指标[用力肺活量(FVC)、第1秒用力呼气量(FEV1)],圣乔治呼吸问卷(SGRQ)评分,血清学细胞因子[白细胞介素(IL)-17、IL-10]及免疫指标(Ig A、Ig M、Ig G)。结果观察组总有效率高于对照组[93.3%(28/30)比80.0%(24/30)](P<0.05)。两组患者治疗后FVC、FEV1高于治疗前(P<0.05),治疗后观察组FVC、FVE1高于对照组(P<0.05);治疗后,两组患者呼吸症状、活动能力、疾病影响及总分均低于治疗前(P<0.05),观察组呼吸症状、活动能力、疾病影响及总分低于对照组(P<0.05);治疗后,两组患者IL-10高于治疗前,且观察组高于对照组(P<0.05);治疗后两组患者IL-17低于治疗前,且观察组低于对照组(P<0.05);治疗后,两组Ig A、Ig M、Ig G均高于治疗前,且观察组高于对照组(P<0.05);两组患者上述各指标组间、时点间、组间和时点间交互作用比较差异有统计学意义(P<0.05)。结论芪龙定喘膏滋联合自血穴位注射用于治疗COPD缓解期患者能改善肺功能,有效控制症状、提高患者免疫功能、降低炎症反应、稳定病情,提高患者生活质量,促进患者康复。
Objective To investigate the clinical effect of Qilong Dingchuan ointment and autologous blood acupoint injection on chronic obstructive pulmonary disease(COPD) in remission stage and its influence on immune function.Methods A total of 60 patients with COPD in remission period in Qinhuangdao Hospital of Traditional Chinese Medicine from Jan.2016 to Jan.2018 were included in the study.According to different treatment methods,they were divided into a control group and an observation group,30 cases each.The control group was treated with salmeterol and fluticasone powder inhalation,while the observation group was treated with Qilong Dingchuan ointment and autologous blood acupoint injection on the basis of the control group’s regimen.Both groups were treated for 30 days.After treatment,the clinical effects of the two groups were compared.The lung function indexes[forced vital capacity(FVC),forced expiratory volume in first second(FEV1)],St.George’s Respiratory Questionnaire(SGRQ) score,serum cytokines[interleukin(IL)-17,IL-10] and immune indexes(Ig A,Ig M,Ig G) were compared before and after treatment.Results The total effective rate of the observation group was higher than that of the control group[93.3%(28/30) vs 80.0%(24/30)](P<0.05).FVC and FEV1 in the two groups were higher than those before treatment(P<0.05),and FVC and FVE1 in the observation group after treatment were higher than those in the control group(P<0.05).After treatment,the respiratory symptoms,the activity ability,the disease influence and the total score of the two groups were lower than those before treatment(P<0.05),and the indexes of the observation group were lower than those of the control group(P<0.05).After treatment,the IL-10 in the two groups was higher than those before treatment,the observation group higher than the control group(P<0.05).After treatment,the IL-17 of both groups was lower than that before treatment,the observation group lower than the control group(P<0.05).After treatment,Ig A,Ig M and Ig G were higher than those be
作者
王虹
杨环玮
WANG Hong;YANG Huanwei(Department of Pulmonary Disease,Qinhuangdao Traditional Chinese Medicine Hospital,Qinhuangdao 066000,China)
出处
《医学综述》
2019年第19期3944-3948,共5页
Medical Recapitulate
基金
河北省中医药管理局科研计划项目(2019532)
关键词
慢性阻塞性肺疾病稳定期
芪龙定喘膏
自血穴位注射
免疫功能
生活质量
Chronic obstructive pulmonary disease in stable/remission stage
Qilong Dingchuan ointment
Autologous blood acupoint injection
Immune function
Quality of life
