摘要
慢性阻塞性肺疾病在全球有很高的发病率和病死率。慢性阻塞性肺疾病的早期防治、提高诊断率和治疗效果对延长患者生命、改善预后及减轻家庭与医疗负担至关重要。目前慢性阻塞性肺疾病的特异性生物学标志物尚未明确,肺表面活性蛋白D(SP-D)是由肺泡Ⅱ型上皮细胞和气道clara细胞合成,分泌到肺泡腔中,对肺组织的防御功能起重要作用,能与细菌、病毒等病原体结合从而促进清除,因此SP-D在呼吸道疾病中发挥着至关重要的作用,在慢性阻塞性肺疾病的诊断、严重程度、治疗、预后评价方面有一定的应用价值。
Chronic obstructive pulmonary disease(COPD) has a high incidence and mortality rate in the world.Early prevention,improvement of diagnosis rate and treatment effect are essential for prolonging the life of patients with COPD,improving the prognosis and reducing family and medical burden.At present,the specific biological markers of COPD are not clear,pulmonary surfactant protein D(SP-D) is synthesized by alveolar type Ⅱ epithelial cells and airway clara cells,secreted into the alveolar space,plays an important role in the defense function of lung tissue,and can bind to pathogens such as bacteria and viruses to promote clearance,SP-D plays a vital role in respiratory diseases,and has certain application value in the diagnosis,severity,treatment and prognosis evaluation of COPD.
作者
梁程程
史家欣
赵新成
李家树
LIANG Chengcheng;SHI Jiaxin;ZHAO Xincheng;LI Jiashu(Department of Respiratory Medicine,Xuzhou Medical University Affiliated Lianyungang Hospital,Liangyungang 222000,China;Department of Respiratory Medicine,Nanjing Medical University Affiliated Lianyungang Clinical College,Lianyungang 222000,China)
出处
《医学综述》
2019年第19期3788-3792,共5页
Medical Recapitulate
基金
国家自然科学基金青年科学基金(81300052)
江苏省卫生计生委科研课题(H201558)
连云港市科技项目(SH1401)
关键词
慢性阻塞性肺疾病
慢性阻塞性肺疾病急性加重
肺表面活性蛋白D
生物学标志物
肺通气功能
Chronic obstructive pulmonary disease
Chronic obstructive pulmonary diseases with acute exacerbation
Pulmonary surfactant protein D
Biomarkers
Pulmonary ventilation function
