摘要
目的探寻中国北方地区2型糖尿病患者摄盐量与非酒精性脂肪性肝病(NAFLD)之间的相关性。方法 选取2016年10月至2018年11月期间在哈尔滨医科大学附属第一医院内分泌科就诊的2型糖尿病患者978例为研究对象。依据是否合并NAFLD分为2组:NAFLD组(n=801)和非NAFLD组(n=177)。采用24h尿钠结果评估患者摄盐量。对比2组患者的体质量指数(BMI)、舒张压(DBP)、收缩压(SBP)、低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、胰岛素总量、糖化血红蛋白(HbA1c)、空腹C肽、空腹血糖(FBG)等临床资料。采用SPSS17.0软件进行统计分析。对单因素分析有统计学意义的指标进行多因素logistic回归分析,筛选出独立的危险因素。采用Spearman相关分析判断受试者摄盐量与NAFLD之间的相关性。结果 Spearman相关分析结果显示,摄盐量与NAFLD呈显著正相关(r=0.129,P<0.001)。多因素logistic回归分析结果显示,BMI(OR=5.321,95%CI3.514~8.057)、HbA1c(OR=1.126,95%CI1.006~1.260)、空腹C肽(OR=1.656,95%CI1.273~2.156)、FBG(OR=1.697,95%CI1.060~2.717)和摄盐量>10.83g/d(10.83g/d<摄盐量≤14.52g/d:OR=2.181,95%CI1.225~3.882;摄盐量>14.52g/d:OR=2.140,95%CI1.167~3.926)是2型糖尿病患者合并NAFLD的危险因素(P<0.05)。结论 高摄盐量(>10.83g/d)是中国北方2型糖尿病患者合并NAFLD的风险因素。
Objective To explore the correlation between salt intake and non-alcoholic fatty liver disease (NAFLD) in type 2 diabetes mellitus (T2DM) patients in northern China. Methods A total of 978 T2DM patients hospitalized in our department from October 2016 to November 2018 were subjected in the study. They were assigned into non-NAFLD group ( n =177) and NAFLD group ( n =801). Their salt intake was assessed by 24-hour urinary sodium excretion.The clinical data such as body mass index (BMI),diastolic blood pressure (DBP),systolic blood pressure (SBP),low-density lipoprotein cholesterol (LDL-C),total cholesterol (TC),total insulin,glycosylated hemoglobin A1c (HbA1c),fasting C-peptide and fasting blood glucose (FBG) were collected and analyzed. SPSS statistics 17.0 was used to analyze the data. After the factors with statistical significance screened out by univariate analysis,the independent risk factors for NAFLD in T2DM patients were identified by multiple logistic regression analysis. Spearman correlation analysis was employed to identify the correlation between salt intake and NAFLD. Results Spearman correlation analysis showed that there was a positive correlation between salt intake and NAFLD in T2DM patients ( r=0.129,P <0.001). The results of multiple logistic regression analysis indicated that BMI ( OR =5.321,95% CI 3.514-8.057),HbA1c ( OR =1.126,95% CI 1.006-1.260),fasting C-peptide ( OR =1.656,95% CI 1.273-2.156),FBG ( OR =1.697,95% CI 1.060-2.717) and salt intake >10.83 g/d (10.83 g/d< salt intake≤14.52 g/d:OR =2.181,95% CI 1.225-3.882;salt intake >14.52 g/d:OR =2.140,95% CI 1.167-3.926 ) were independent risk factors for NAFLD in T2DM patients ( P <0.05). Conclusion High salt intake (>10.83 g/d) is a risk factor for NAFLD in T2DM patients living in northern China.
作者
梁苡菲
匡洪宇
秦文
朱文博
刘念娇
左姣
韩爽
LIANG Yi-Fei;KUANG Hong-Yu;QIN Wen;ZHU Wen-Bo;LIU Nian-Jiao;ZUO Jiao;HAN Shuang(Department of Endocrinology,First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)
出处
《中华老年多器官疾病杂志》
2019年第10期765-768,共4页
Chinese Journal of Multiple Organ Diseases in the Elderly
关键词
摄盐量
尿钠
糖尿病
非酒精性脂肪性肝病
salt intake
urine sodium
diabetes mellitus
non-alcoholic fatty liver disease
