摘要
目的探讨多层螺旋CT与血清糖类抗原125(CA125)对晚期卵巢癌满意减瘤术的预测价值。方法回顾性分析我院收治的84例晚期卵巢癌患者的临床资料,均行腹盆腔多层螺旋CT检查,先行新辅助化疗,再行间期卵巢癌减瘤术,化疗前和术前均检测血清CA125水平,分析血清CA125水平和Jonathan评分对减瘤术满意率的影响。结果治疗满意62例,满意率为73.81%(62/84)。满意组与不满意组年龄、FIGO分期、病理分级、病理类型及化疗前CA125水平比较,差异均无统计学意义(P>0.05);两组术前CA125水平和下降幅度存在显著差异(P<0.05);术前CA125水平≤500U/ml组减瘤术满意率明显高于>500U/ml组(P<0.05),CA125下降幅度≥80%减瘤术满意率明显高于下降幅度<80%组(P<0.05);≤3分组的减瘤术满意率为91.80%(56/61),明显高于>3分组的30.43%(7/23)(P<0.05);术前CA125水平、CA125下降幅度和Jonathan评分是能否行卵巢癌满意减瘤术的独立影响因素(P<0.05)。结论多层螺旋CT与血清CA125水平对晚期卵巢癌能否行满意减瘤术有一定的预测价值,可为术前评估和合理的临床决策提供参考依据。
Objective To explore the predictive value of multi-slice spiral CT and serum carbohydrate antigen 125 (CA125) for satisfactory cytoreductive surgery of advanced ovarian cancer.Methods The clinical data of 84 patients with advanced ovarian cancer admitted to our hospital were retrospectively analyzed.All patients were given abdominal pelvic multi-slice spiral CT,and firstly given neoadjuvant chemotherapy and then interstage ovarian cancer cytoreductive surgery.Serum CA125 level was detected before chemotherapy and before surgery,and the effects of serum CA125 level and Jonathan score on the satisfaction rate of cytoreductive surgery were analyzed.Results 62 patients were satisfied with treatment,and the satisfaction rate was 73.81%(62/84).There were no significant differences in the age,FIGO stage,pathological grades,pathological types and CA125 level before chemotherapy between satisfactory group and unsatisfactory group (P>0.05).There were significant differences in the preoperative CA125 level and the decrease range between the two groups (P<0.05).The satisfaction rate of cytoreductive surgery in preoperative CA125 level≤500U/ml group was significantly higher than that in >500U/ml group (P<0.05),and the satisfaction rate of cytoreductive surgery in CA125 decrease range ≥80% group was significantly higher than that in decrease range<80% group (P<0.05).The satisfaction rate of cytoreductive surgery in ≤3 points group was significantly higher than that in >3 points group [91.80%(56/61) vs 30.43%(7/23)](P<0.05).The preoperative CA125 level,decrease range of CA125 and Jonathan score were independent influencing factors for the implementation of satisfactory cytoreductive surgery of ovarian cancer (P<0.05).Conclusion Multi-slice spiral CT and serum CA125 level have certain predictive value for satisfactory cytoreductive surgery of advanced ovarian cancer,and they can provide reference for preoperative evaluation and reasonable clinical decision-making.
作者
刘斌
宋庆伦
LIU Bin;SONG Qing-lun(Department of Radiology,West District Hospital of Chendu,Chengdu 610000,Sichuan Province,China)
出处
《中国CT和MRI杂志》
2019年第10期102-104,123,共4页
Chinese Journal of CT and MRI
关键词
多层螺旋CT
血清糖类抗原125
卵巢癌
减瘤术
Multi-slice Spiral CT
Serum Carbohydrate Antigen 125
Ovarian Cancer
Cytoreductive Surgery
