摘要
考察了苄基三乙基氯化铵等7种相转移催化剂对N-甲基氰胺基甲酸乙酯N-甲基化反应的影响.确立了在同等反应条件下苄基三甲基氯化铵催化活性最高,当n(单氰胺)∶n(苄基三甲基氯化铵)=1.00∶0.03时,N-甲基氰铵基甲酸乙酯N-甲基化反应的收率达93.3%.
The catalytic activities of several common phase transfer catalysts in the synthesis of ethyl N-cyano-Nmethylcarbamate were compared. The catalytic activity of benzyltrimethylammonium chloride was the highest under the same reaction conditions. When the molar ratio of monocyanamide to benzyltrimethylammonium chloride was 1.00 ∶ 0.03, the yield of the reaction was the highest one with 93.3%.
作者
黄炜
陈新年
刘雄军
罗先福
HUANG Wei;CHEN Xin-nian;LIU Xiong-jun;LUO Xian-fu(National Engineering Research Center for Agrochemicals, Hunan Research Institute of Chemical Industry,Changsha 410014, China;Hunan Province Key Laboratory for Agrochemicals, Changsha 410014, China;Hunan Haili Changde Pesticide & Chemical Industry Co.,Ltd., Changde 415000, China)
出处
《精细化工中间体》
CAS
2019年第4期20-22,共3页
Fine Chemical Intermediates
基金
湖湘青年英才(2019RS2060)
国家自然科学基金(21572050)
