摘要
DHX9又称为核DNA解旋酶Ⅱ或RNA解旋酶A,属于DExH-box家族,是一种能解开RNA、DNA及异常多聚核苷酸结构的dNTP依赖性解旋酶蛋白.DHX9主要由DExH解旋酶和DExD解旋酶构成,在DNA复制、转录、翻译,RNA加工及转录,维持基因稳定性等方面具有重要的调控作用.研究表明D H X9与乳腺癌、肺癌等多种恶性肿瘤的发生密切相关,可能成为恶性肿瘤治疗的新靶点.目前在异体移植模型中已有针对DHX9的靶向药物,并有希望进行下一步临床实验.现主要就DHX9在乳腺癌、肺癌等恶性肿瘤发生、发展中的作用及治疗作一简要总结.
DHX9 ,also known as nuclear DNA helicase Ⅱ or RNA Helicase A ,belongs to the DExH-box family and is an dNTP-dependent helicase protein that unwinds RNA ,DNA and abnormal polynucleotide structures .DHX9 is mainly composed of DExH helicase and DExD helicase ,and plays an important regulatory role in DNA replication ,transcription ,translation ,RNA processing and transcription ,and maintenance of gene stability .Studies have shown that DHX 9 is closely related to the occurrence of various malignant tumors such as breast cancer and lung cancer , and may become a new target for the treatment of malignant tumors .Currently ,there are targeted drugs for DHX9 in the allograft model ,and there is hope for further clinical trials .This is a brief summary of the role and treatment of DHX9 in the development and progression of malignant tumors such as breast cancer and lung cancer .
作者
马娟
赵楠楠
杨拴盈
Ma Juan;Zhao Nannan;Yang Shuanying(Department of Respiratory and Critical Care Medicine, Second Affiliated Hospital of Xi' an Jiaotong University, Xi'an 710000, China)
出处
《国际呼吸杂志》
2019年第18期1407-1411,共5页
International Journal of Respiration
