摘要
目的探讨肝恶性肿瘤的病理边缘浸润距离与肿瘤类型及超声影像学特征的关系。方法对78例肝恶性肿瘤患者行二维超声、超声造影检查及超声引导下肝肿物及周边肝组织穿刺活检,并行病理标本HE染色,记录肿瘤边缘浸润情况。结果肝细胞癌、胆管细胞癌、转移性肝癌肿瘤边缘浸润发生率分别为62.5%(30/48)、87.5%(7/8)、91.0%(20/22),二维超声边界清晰与边界不清的肿瘤边缘浸润发生率分别为50%(14/28)、86%(43/50),肿瘤类型、二维超声边界是影响肿瘤边缘浸润发生率的独立预测因素(均P<0.05);肝细胞癌、胆管细胞癌、转移性肝癌中位肿瘤边缘浸润距离分别为1.0(0,3.0)mm、4.0(2.3,4.0)mm、2.0(1.8,4.0)mm,肿瘤边缘浸润距离随肿瘤增大而增大,肿瘤类型、肿瘤最大径是影响肿瘤边缘浸润距离的独立预测因素(均P<0.05)。结论对于胆管细胞癌、转移性肝癌、体积较大或二维超声边界显示不清的肿瘤,边缘浸润距离增大。
Objective To study the relationships between microscopic marginal extensions and tumor types, and ultrasonic characteristics of malignant liver tumors. Methods Two-dimensional ultrasonography, contrast-enhanced ultrasonography and ultrasound-guided biopsy of hepatic tumors and surrounding hepatic tissues were performed in 78 patients with malignant liver tumor. Pathological microscopic extensions were observed after hematoxylin-eosin staining of biopsy specimens. Results The microscopic marginal extension rates of hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC) and metastatic liver cancer (MLC) were 62.5%(30/48), 87.5%(7/8), and 91.0%(20/22), respectively. For tumors with well-defined and poorly-defined two-dimensional ultrasound boundary, microscopic marginal extension rates were 50%(14/28), and 86%(43/50). Tumor type and two-dimensional ultrasound boundary were independent predictors for microscopic extension rate (P<0.05). The median microscopic extension distances of HCC, ICC and MLC were 1.0(0, 3.0)mm, 4.0(2.3, 4.0)mm, and 2.0(1.8, 4.0)mm, respectively. The distance of microscopic extension increased with tumor size. Tumor type and tumor size were independent predictors for the distance of microscopic extension (P<0.05). Conclusions ICC, MLC, and tumors with larger diameter or poorly-defined two-dimensional ultrasound boundary have a larger distance of microscopic extension.
作者
钟娴
谢晓华
康继辉
庄博文
谢晓燕
Zhong Xian;Xie Xiaohua;Kang Jihui;Zhuang Bowen;Xie Xiaoyan(Institute of Diagnostic and Interventional Ultrasound,Sun Yat-Sen University & Department of Ultrasound,the First Affiliated Hospital of Sun Yat-Sen University,Guangzhou 510080,China;Department of Pathology,the First Affiliated Hospital of Sun Yat-Sen University,Guangzhou 510080,China)
出处
《中华超声影像学杂志》
CSCD
北大核心
2019年第9期759-765,共7页
Chinese Journal of Ultrasonography
基金
国家自然科学基金重点项目(81530055).
关键词
超声检查
超声造影
肝恶性肿瘤
肿瘤微浸润
Ultrasonography
Contrast-enhanced ultrasonography
Liver tumors
Tumor micro-invasion
