摘要
目的探讨不同剂量辛伐他汀治疗老年高血压合并高脂血症的临床疗效和安全性。方法选取2017年5月至2018年5月于本院治疗的老年高血压合并高脂血症患者160例,以其入院先后顺序分成两组,其中小剂量组纳入80例,大剂量组纳入80例。两组患者均给予常规的降压治疗,在此基础上联合应用辛伐他汀,小剂量组患者每次给予20mg,每天1次,于晚餐后口服;大剂量组患者每次给予40mg,每天1次,于晚餐后口服。观察比较两组患者血压控制效果、血脂改善情况及不良反应发生情况。结果大剂量组患者治疗4周时的SBP(128.5±5.7)mmHg、DBP(88.3±2.9)mmHg,均显著低于小剂量组的SBP(140.8±7.4)mmHg、DBP(96.4±3.8)mmHg,组间比较差异具有统计学意义(P<0.05)。但大剂量组患者治疗10周时的SBP(117.7±4.3)mmHg、DBP(76.3±2.2)mmHg,与小剂量组的SBP(119.4±4.8)mmHg、DBP(79.7±2.8)mmHg相当,组间比较差异无统计学意义。大剂量组治疗4周时的TC(4.12±0.84)mmol/L、TG(2.12±0.10)mmol/L、LDL-C(2.90±0.66)mg/ml,均显著低于小剂量组的TC(5.16±0.97)mmol/L、TG(2.44±0.22)mmol/L、LDL-C(4.01±0.86)mg/ml,组间比较差异具有统计学意义(P<0.05);但大剂量组患者治疗10周时的TC(3.08±0.61)mmol/L、TG(2.02±0.02)mmol/L、LDL-C(2.08±0.45)mg/ml,与小剂量组的TC(3.21±0.66)mmol/L、TG(2.08±0.04)mmol/L、LDL-C(2.14±0.51)mg/ml相比差异无统计学意义。两组患者均未见横纹肌溶解、肝功能异常等较为严重的不良反应,其中大剂量组出现头晕1例、便秘1例、皮疹1例,不良反应发生率为3.75%(3/80);小剂量组出现头晕1例,腹痛1例、胃肠胀气1例,不良反应发生率为3.75%(3/80);组间比较差异无统计学意义。结论采用辛伐他汀治疗老年高血压合并高脂血症患者的过程中,应当在早期采用大剂量治疗,后期改为小剂量治疗,可获得较好的治疗效果和安全性。
Objective To explore the clinical efficacy and safety of different doses of simvastatin in the treatment of senile hypertension complicated with hyperlipidemia. Methods The selected subjects were 160 elderly patients with hypertension and hyperlipidemia treated in our hospital during May 2017 to May 2018. They were divided into two groups according to their admission sequence. 80 cases were included in the low-dose group and 80 cases in the high-dose group. Two groups of patients were given routine antihypertensive treatment, combined with simvastatin, small dose group was given 20 mg per time, once a day, after dinner;large dose group was given 40 mg per time, once a day, after dinner.Blood pressure control effect, blood lipid improvement and adverse reactions were observed and compared between the two groups. Results SBP (128.5± 5.7) mmHg and DBP (88.3±2.9) mmHg were significantly lower in the high-dose group than those in the low-dose group (140.8±7.4) mmHg and DBP (96.4±3.8) mmHg at 4 weeks of treatment. There were significant differences between the two groups (P<0.05). However, SBP (117.7± 4.3) mmHg and DBP (76.3±2.2) mmHg at 10 weeks of treatment in large dose group were similar to those in small dose group (119.4±4.8) mmHg and DBP (79.7±2.8) mmHg, but there was no significant difference between the two groups. The TC (4.12±0.84) mmol/L, TG (2.12±0.10) mmol/L, LDL-C (2.90±0.66) mg/ml at 4 weeks of treatment in high dose group were significantly lower than those in low dose group (5.16±0.97) mmol/L, TG (2.44±0.22)mmol/L, LDL-C (4.01±0.86) mg/ml, and there were significant differences between groups (P<0.05). TC (3.08±0.61) mmol/L, TG (2.02± 0.22) mmol/L, LDL-C (2.08±0.45) mg/ml at week time were similar to those of low-dose group in TC (3.21±0.66) mmol/L, TG (2.08±0.04) mmol/L, LDL-C (2.14±0.51) mg/ml, but there was no significant difference between groups. There were no serious adverse reactions such as rhabdomyolysis and abnormal liver function in both groups, including 1 case of dizzi
作者
罗时梅
魏春华
Luo Shimei;Wei Chunhua(Department of Pharmacy, Nanjing Gaochun Hospital of Traditional Chinese Medicine, Nanjing, Jiangsu, 211300, China)
出处
《当代医学》
2019年第29期17-20,共4页
Contemporary Medicine
关键词
不同剂量
辛伐他汀
老年
高血压合并高脂血症
临床疗效
安全性
Different dosage
Simvastatin
Elderly
Hypertension with hyperlipidemia
Clinical efficacy
Safety
