摘要
目的:探讨锁定加压接骨板内固定治疗Robinson 2A、2B型锁骨中段骨折对创伤程度、骨代谢的影响。方法:选择本院收治的Robinson 2A、2B型锁骨中段骨折患者80例,回顾性分析其手术方案分为接受常规克氏针内固定治疗的对照组41例、接受锁定加压接骨板内固定治疗的观察组39例。对比两组入手术室前、术后24 h、术后48 h血清中炎症因子、氧化应激指标、骨代谢指标含量的差异。结果:入手术室前,两组血清中炎症因子、氧化应激指标、骨代谢指标含量比较,差异无统计学意义(P>0.05)。术后24、48 h,观察组血清中炎症因子白介素-1(IL-1)、白介素-17(IL-17)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子α(TNF-α)的含量低于对照组;血清中活性氧(ROS)、脂质过氧化氢(LHP)的含量低于对照组,过氧化氢酶(CAT)、谷胱甘肽过氧化物酶(GSH-Px)的含量高于对照组;血清中Ⅰ型前胶原氨基末端前肽(PⅠNP)、骨钙素(BGP)、碱性磷酸酶(ALP)的含量高于对照组患者,Ⅰ型胶原N端肽(NTX)、Ⅰ型胶原C端肽(CTX)、抗酒石酸酸性磷酸酶5b(TRACP5b)的含量低于对照组(P<0.05)。结论:锁定加压接骨板内固定治疗可减轻Robinson 2A、2B型锁骨中段骨折患者的术后创伤程度,有助于促进骨折愈合。
Objective:To investigate the effect of locking compression plate internal fixation on the injury extent and bone metabolism of Robinson 2 A and 2 B middle clavicular fractures.Methods:80 cases of patients with Robinson 2 A and 2 B middle clavicular fractures admitted to our hospital between March 2017 and January 2019 were divided into the control group(n=41)receiving conventional kirschner wire internal fixation and the observation group(n=39)receiving locking compression plate internal fixation according to the operation plans.The differences in serum contents of inflammatory factors,oxidative stress indexes and bone metabolism indexes were compared between the two groups of patients before patients entered operating room,24 h after surgery and 48 h after surgery.Results:Before patients entered operating room,there were no statistically significant differences in the serum contents of inflammatory factors,oxidative stress indexes or bone metabolism indexes between the two groups(P>0.05).At 24 h and 48 h after surgery,serum inflammatory factors interleukin-1(IL-1),interleukin-17(IL-17),high-sensitivity C-reactive protein(hs-CRP)and tumor necrosis factorα(TNF-α)contents in the observation group were lower than those in the control group;serum reactive oxygen species(ROS)and lipid hydroperoxide(LHP)contents were lower than those in the control group,while catalase(CAT)and glutathione peroxidase(GSH-Px)contents were higher than those in the control group;serum N-terminal propeptide of procollagen type I(PINP),bone gla protein(BGP)and alkaline phosphatase(ALP)contents were higher than those in the control group,while N-telopeptide of typeⅠcollagen(NTX),C-telopeptide of typeⅠcollagen(CTX)and tartrate-resistant acid phosphatase 5 b(TRACP5 b)contents were lower than those in the control group(P<0.05).Conclusion:Locking compression plate internal fixation can reduce the postoperative trauma extent and help promote the fracture healing in patients with Robinson 2 A and 2 B middle clavicular fracture.
作者
方文广
林扬
黄立成
杜贵忠
FANG Wen-guang;LIN Yang;HUANG Li-cheng;DU Gui-zhong(Surgery Department No. 2,the Sixth People's Hospital of Huiyang Huizhou Guangdong Province,Huizhou,Guangdong Province,516211)
出处
《海南医学院学报》
CAS
2019年第16期1242-1246,共5页
Journal of Hainan Medical University
基金
惠州市科技计划项目(20150802)~~
关键词
锁骨中段骨折
锁定加压接骨板内固定
创伤
骨代谢
Middle clavicular fracture
Locking compression plate internal fixation
Trauma
Bone metabolism
