摘要
目的观察老年全髋关节置换术应用右美托咪定对认知功能与炎症反应的影响。方法选取2016 年10 月—2018年10 月南雄市人民医院收治的80 例老年全髋关节置换手术患者,采用随机数表法分为两组,每组各40 例。观察组予以右美托咪定泵注镇静,对照组使用生理盐水。比较两组简易智力状态检查量表(Mini-mental state examination,MMSE)评分、炎症反应指标[肿瘤坏死因子-α(Tumour necrosis factor-α,TNF-α)、白介素(Interleukin,IL)-6、IL-1β]水平以及术后康复情况。结果两组术后MMSE 评分均较术前降低,但观察组降幅小于对照组,差异有统计学意义(P <0.05);两组术毕时TNF-α、IL-1β以及IL-6 水平均较麻醉前提高,但观察组升幅小于对照组,差异有统计学意义(P <0.05)。结论针对老年全髋关节置换术患者,予以右美托咪定镇静利于维护认知功能,减轻炎症反应,效果确切。
Objective To observe the effect of dexmedetomidine on cognitive function and inflammatory response in elderly pa tients undergoing total hip arthroplasty. Methods 80 elderly patients undergoing total hip arthroplasty in the hospital from October, 2016 to October,2018 were selected. They were divided into two groups by random number table,with 40 cases in each group. The observation group were sedated by dexmedetomidine pump,while the control group were sedated by normal saline. The Mini-mental state examination(MMSE)score,inflammatory response index [Tumour necrosis factor-alpha(TNF-alpha),interleukin(IL)-6, IL-1beta] and postoperative rehabilitation were compared between the two groups. Results The MMSE scores of the two groups were lower than those of the control group,but the decrease of the observation group was less than that of the control group(P<0.05);the levels of TNF-alpha,IL-1beta and IL-6 were higher than those before anesthesia,but the increase of the observation group was less than that of the control group. The difference was statistically significant(P<0.05). Conclusion For elderly patients undergoing total hip arthroplasty,sedation with dexmedetomidine is beneficial to maintaining cognitive function and alleviating inflammation.
作者
许骥
XU Ji(Anesthesiology Department,Nanxiong People’s Hospital,Nanxiong,Guangdong,512400,China)
出处
《黑龙江医学》
2019年第9期1034-1035,共2页
Heilongjiang Medical Journal
关键词
老年全髋关节置换术
右美托咪定
认知功能
炎症反应
Total hip arthroplasty in the elderly
Dexmedetomidine
Cognitive function
Inflammatory response
