摘要
目的 探讨肝动脉栓塞术(TAE)和肝动脉化疗栓塞术(TACE)治疗原发性肝癌的效果及对肝功能分级的影响.方法 选取该院肿瘤科2014年2月至2017年12月收治的200例原发性肝癌患者开展回顾性分析,依据介入治疗方式不同将以上研究对象分为TAE组(95例)和TACE组(105例),TAE组行TAE治疗,TACE组行TACE治疗,比较两组的临床疗效、病灶直径、介入次数、甲胎蛋白(AFP)水平、肝功能分级及并发症情况.随访1年,比较两组的生存率.结果 TAE组的有效率为55.79%,TACE组的有效率为55.24%,两组比较,差异无统计学意义(P>0.05);两组的病灶直径及AFP水平比较,差异无统计学意义(P>0.05);TAE组的介入手术次数显著低于TACE组,差异有统计学意义(P<0.05);两组术后肝功能分级均有好转,且两组比较,差异无统计学意义(P>0.05);TAE组的并发症发生率为22.11%,TACE组的并发症发生率为26.67%,两组比较,差异无统计学意义(P>0.05);TAE组的1年生存率为54.74%,TACE组的1年生存率为55.24%,两组比较,差异无统计学意义(P>0.05).结论 TAE与TACE均能有效治疗原发性肝癌,且两者疗效相当,TAE相较于TACE能够减少介入治疗次数,避免化疗药物对于肝脏的损伤.
Objective To explore the effects of transcatheter arterial embolization (TAE) and transcatheter arterial chemoembolization (TACE) in the treatment of primary liver cancer and its influence on liver function grading. Methods A total of200 patients with primary liver cancer admitted to department of oncology of our hospital from February2014 to December2017 were retrospectively analyzed.The above subjects were divided into TAE group (95 cases) and TACE group (105 cases) according to different interventional methods.TAE group was given TAE treatment,and TACE group was given TACE therapy.The clinical efficacy,lesion diameter,interventions frequency,alpha fetoprotein (AFP) level,liver function grading and complications were compared between the two groups.The survival cycle was compared between the two groups. Results The effective rates of TAE group and TACE group were 55.79% and 55.24%,differences were not statistically ( P>0.05 ).There were no significant differences in the lesion diameter and AFP level between the two groups ( P>0.05 ).The frequency of interventional procedures in TAE group was significantly lower than that in TACE group ( P<0.05).The liver function grading in the two groups was improved,and there was no significant difference between the two groups ( P>0.05).The incidence rates of complications in TAE group and TACE group were22.11% and26.67%,and there was no significant difference between the two groups ( P>0.05).The1-year survival rates of TAE group and TACE group were 54.74% and 55.24%,and there was no significant difference between the two groups ( P>0.05). Conclusion Both TAE and TACE could effectively treat primary liver cancer,and the two methods have similar efficacy.TAE could reduce the frequency of interventional treatments and avoid the liver damage caused by chemotherapy drugs compared with TACE.
作者
李成业
LI Chengye(Department of Intervention,Central Hospital of Mining Bureau of Tongchuan,Tongchuan,Shaannxi 727000,China)
出处
《检验医学与临床》
CAS
2019年第18期2634-2636,2639,共4页
Laboratory Medicine and Clinic
关键词
肝动脉栓塞术
肝动脉化疗栓塞术
原发性肝癌
transcatheter arterial embolization
transcatheter arterial chemoembolization
primary liver cancer
