摘要
急性胰腺炎是累及胰腺及其周围组织的炎性病变,其中重症急性胰腺炎(severe acute pancreatitis,SAP)可引起器官衰竭,病死率较高。入院后最初24 h内的早期干预对改善SAP预后至关重要。有证据提示,早期预测SAP疾病严重程度、充分补液及早期肠内营养有助于改善临床转归。不加选择地预防性应用抗生素及早期经内镜逆行性胰胆管造影术对SAP患者无效。但现有多数研究样本量较小,证据级别较低,有待更多高质量的研究阐明SAP患者早期的治疗选择。
Acute pancreatitis is an inflammatory entity involving the pancreas and peri-pancreatic tissues.Severe acute pancreatitis leads to persistent organ failure and high mortality.Treatment in the first 24 hours of admission is crucial for the prognosis.Current evidence indicates that adequate fluid resuscitation with lactated Ringer’s and early enteral nutrition may be effective,but prophylactic antibiotics and early ERCP should not be routinely used.The small sample size is a major limitation for current research.Large scale,multi-center randomized controlled trials are eagerly awaited.
作者
孙翰
柏小寅
吴东
SUN Han;BAI Xiao-yin;WU Dong(Department of Gastroenterology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100730,China)
出处
《协和医学杂志》
CSCD
2019年第5期514-517,共4页
Medical Journal of Peking Union Medical College Hospital
关键词
急性胰腺炎
重症急性胰腺炎
补液
早期干预
治疗
acute pancreatitis
severe acute pancreatitis
fluid therapy
early intervention
treatment
