摘要
目的研究地塞米松注射液不同给药方式对低频下降型突发性耳聋患者疗效及预后的影响,为患者的临床治疗提供指导。方法选择韩城市人民医院2016年1月至2019年2月收治的100例低频下降型突发性耳聋患者进行研究,根据随机数表法将其分为对照组和观察组各50例。对照组患者采取地塞米松注射液全身静脉滴注治疗,观察组采取地塞米松注射液耳后注射治疗,疗程为10 d。治疗10 d后比较两组患者的疗效、治疗前后的平均听阈和血液流变学(全血高切黏度、全血低切黏度、血浆黏度)以及不良反应情况。结果观察组患者的临床治疗总有效率为96.0%,明显高于对照组的84.0%,差异有统计学意义(P<0.05);治疗前,两组患者的平均听阈比较差异无统计学意义(P>0.05),治疗后,两组患者的平均听阈较治疗前均明显降低,差异均有统计学意义(P<0.05),但组间比较差异无统计学意义(P>0.05);治疗前,观察组患者的全血高切黏度、全血低切黏度、血浆黏度分别与对照组比较差异均无统计学意义(P>0.05),治疗后,两组患者的全血高切黏度、全血低切黏度、血浆黏度较治疗前均明显降低,但观察组全血高切黏度、全血低切黏度、血浆黏度降低较对照组更明显,差异均有统计学意义(P<0.05);观察组患者的不良反应发生率为4.0%,明显低于对照组的16.0%,差异有统计学意义(P<0.05)。结论耳后注射地塞米松能够有效提高治疗效果,明显改善患者的平均听阈和血液流变学指标,减少不良反应的发生,而全身静脉滴注的副作用较大,提倡使用耳后注射地塞米松治疗低频下降型突发性耳聋。
Objective To study the effects of different administration methods of dexamethasone injection on the efficacy and prognosis of patients with low-frequency descending type sudden deafness, and provide guidance for clinical treatment. Methods A total of 100 patients with low-frequency descending type sudden deafness were selected in this study, who were admitted to Hancheng People’s Hospital from January 2016 to February 2019. According to the random number table method, they were divided into control group and observation group, with 50 cases in each group.The patients in the control group were treated with dexamethasone injection through a systemic intravenous infusion.The patients in the observation group were treated with dexamethasone injection through a retroauricular injection. Both treatments were 10 days. After 10 days of treatment, the curative effects of the two groups were compared, as well as the mean hearing threshold and hemorheology before and after treatment(whole blood high shear viscosity, whole blood low shear viscosity, plasma viscosity), and adverse reactions. Results The total effective rate of clinical treatment in the observation group was 96.0%, which was significantly higher than 84.0% in the control group, and the difference was statistically significant(P<0.05). Before treatment, there was no significant difference in the mean hearing threshold between the two groups(P>0.05). After treatment, the mean hearing thresholds of both groups were significantly lower than those before treatment(P<0.05);but there were no significant differences between the two groups(P>0.05). Before treatment, the whole blood high shear viscosity, whole blood low shear viscosity, and plasma viscosity in the observation group were not significantly difference from those of the control group(P>0.05). After treatment, the whole blood high shear viscosity, whole blood low shear viscosity, and plasma viscosity of the two groups were significantly lower than those before treatment;and the decrease in the data mentio
作者
樊建华
石润
齐勍
FAN Jian-hua;SHI Run;QI Qing(Department ofOtolaryngology,Hancheng People's Hospital,Weinan 705499,Shaanxi,CHINA;Department of Ophthalmology and Otorhinolaryngology,Health Promotion Center,Baoji Maternal and Child Health Hospital,Baoji 721000,Shaanxi,CHINA)
出处
《海南医学》
CAS
2019年第17期2259-2261,共3页
Hainan Medical Journal
关键词
地塞米松
耳后注射
静脉滴注
低频下降型
突发性耳聋
疗效
预后
Dexamethasone
Retroauricular injection
Intravenous infusion
Low-frequency descending type
Sudden deafness
Efficacy
Prognosis
