摘要
目的探讨黄体酮联合低分子肝素钠治疗复发性流产的临床疗效及对患者雌二醇(E_2)、孕酮(P)、国际标准化比值(INR)、D-二聚体(D-D)、辅助性T细胞1(Th1)/辅助性T细胞2(Th2)及γ干扰素(IFN-γ)水平的影响。方法选取医院2017年3月至2018年3月收治的复发性流产患者72例,按治疗方法的不同分为对照组和试验组,各36例。两组患者均予黄体酮注射液肌肉注射(每日1次,每次20 mg),试验组患者加用低分子肝素钠注射液(每日1次,每次5 000 IU),均治疗至孕12周。结果试验组保胎成功率为88. 89%,显著高于对照组的66. 67%(P <0. 05);与治疗前比较,两组患者治疗后的E_2,P,INR水平均显著升高,D-D,Th1/Th2,IFN-γ水平均显著降低(P <0. 05);且试验组上述指标改善程度均显著优于对照组(P <0. 05);试验组与对照组不良反应发生率相当(11. 11%比8. 33%,χ^2=0. 158,P=0. 691> 0. 05)。结论黄体酮联合低分子肝素钠治疗复发性流产可有效改善E_2,P,INR,D-D,Th1/Th2,IFN-γ水平,提高保胎成功率,且不增加不良反应。
Objective To investigate the clinical efficacy of progesterone combined with low molecular weight heparin sodium in the treatment of recurrent abortion and its effect on the levels of estradiol ( E 2 ),progesterone ( P ),international normalized ratio ( INR ),D - dimer ( D - D ),helper T cell 1 ( Th1 )/helper T cell 2 ( Th2 ) and interferon -γ( IFN -γ). Methods Totally 72 patients with recurrent abortion admitted to our hospital from March 2017 to March 2018 were selected and divided into the control group and the experimen- tal group according to the different treatment methods,36 cases in each group. The patients in the two groups were given Progesterone Injection by intramuscular injection ( once a day,20 mg each time ). The patients in the experimental group were treated with Low Molecular Weight Heparin Sodium Injection ( once a day,5 000 IU each time ). The patients in the two groups were treated until 12 weeks of gestation. Results The success rate of preventing miscarriage in the experimental group was 88. 89%,which was significantly higher than 66. 67% in the control group ( P < 0. 05 ). Compared with those before treatment,the levels of E 2 ,P and INR were signifi- cantly increased,while the levels of D -D,Th1 /Th2 and IFN -γ were significantly decreased in the two groups after treatment ( P < 0. 05 ), and the improvement of the above indexes in the experimental group was significantly better than that in the control group ( P < 0. 05 ). The incidence of adverse reactions in the experimental group was similar to that in the control group ( 11. 11% vs. 8. 33%,χ^2 = 0. 158, P =0. 691 > 0. 05 ). Conclusion Progesterone combined with low molecular weight heparin sodium in the treatment of recurrent abortion can effectively improve the levels of E 2 ,P,INR,D - D,Th1 /Th2 and IFN -γ,and improve the success rate of preventing miscarriage without increasing adverse reactions.
作者
郑桂英
张粉叶
谷世敏
盖佳
刘莎
ZHENG Guiying;ZHANG Fenye;GU Shimin;GAI Jia;LIU Sha(Shahe People' s Hospital,Xingtai,Hebei,China054100)
出处
《中国药业》
CAS
2019年第18期75-77,共3页
China Pharmaceuticals
基金
河北省邢台市科技计划项目[2017ZC167]
关键词
黄体酮
低分子肝素钠
复发性流产
保胎效果
孕激素水平
progesterone
low molecular weight heparin sodium
recurrent abortion
effect of preventing miscarriage
progesterone level
