摘要
目的探讨在双相躁狂治疗中,奥氮平合并碳酸锂及丙戊酸钠的用药方案的临床效果。方法选取我院2015 年1 月-2018 年9 月接诊的33 例双相躁狂患者,采取奥氮平、碳酸锂联合丙戊酸钠用药方案,奥氮平(每日2 次,总剂量10 mg)、碳酸锂(每日2 ~ 3 次,每次20 ~ 25 mg/kg)、丙戊酸钠(每日2 ~ 3 次,每次15 mg/kg),对患者进行3 个月—2 年的跟踪随访,以末次虽然为准,观察患者治疗前后躁狂量表(Bech-Rafaelsdn Mania Rating Scale,BRMS)变化及临床效果。结果治疗后BRMS 测评结果显著低于治疗前,差异有统计学意义(P <0.05);32 例患者,1 例脱落,治疗前BRMS 测评结果显著低于治疗后,差异有统计学意义(P <0.05);本组32 例患者,总有效率为81.25%,复发率为18.75%。结论奥氮平合并碳酸锂及丙戊酸钠用药方案可有效改善双相躁狂患者的临床症状,保证治疗效果。
Objective To explore the clinical effect of olanzapine combined with lithium carbonate and sodium valproate in the treatment of bipolar mania. Methods Thirty-three bipolar mania patients in our hospital from January 2015 to September 2018 were selected and followed up for 3 months to 2 years with olanzapine and lithium carbonate combined with sodium valproate, olanzapine (twice a day, total dose of 10 mg), lithium carbonate (2-3 times a day, 20-25 mg/kg each time) and sodium valproate (2-3 times a day, 15 mg/kg each time). To observe the changes of mania scale (BRMS) and its clinical effect before and after treatment. Results The results of BRMS after treatment were significantly lower than those before treatment, with statistical significance (P < 0.05);32 patients, 1 case dropped off, the results of BRMS before treatment were significantly lower than those after treatment, with statistical significance (P < 0.05);32 patients in this group, the total effective rate was 81.25%, the recurrence rate was 18.75%. Conclusion Olanzapine combined with lithium carbonate and sodium valproate can effectively improve the clinical symptoms of bipolar mania and ensure the therapeutic effect.
作者
张伟
ZHANG Wei(Department of Psychiatry, Zaozhuang Mental Health Center,Zaozhuang shandong 277103, China)
出处
《中国继续医学教育》
2019年第25期152-154,共3页
China Continuing Medical Education
关键词
双相躁狂
奥氮平
碳酸锂
丙戊酸钠
用药
效果
bipolar mania
olanzapine
lithium carbonate
sodium valproate
medication
effect
