摘要
目的分析北京安定医院精神科门诊双相情感障碍患者用药现状,比较双相障碍躁狂相患者和双相障碍抑郁相患者的用药情况,为临床合理用药提供参考。方法选择门诊102例双相情感障碍患者,分析双相障碍躁狂相及双相障碍抑郁相的心境稳定剂、非典型抗精神病药、抗焦虑药物、抗抑郁药物使用率及剂量的差异。结果 102例患者中,使用心境稳定剂者77例,占75.49%,双相躁狂患者使用丙戊酸盐剂量较大;使用非典型抗精神病药者93例,占91.18%,双相躁狂患者喹硫平和奥氮平的使用剂量较大;服苯二氮卓类抗焦虑药者62例,占60.78%,双相躁狂患者氯硝西泮的使用剂量高于双相抑郁患者;78例双相抑郁患者中服用抗抑郁药24例,占30.77%,安非他酮和氟西汀使用较多。结论国内双相情感障碍药物处方方式与国内外的指南推荐方案基本相符;非典型抗精神病药在双相躁狂和双相抑郁患者的使用非常广泛;抗焦虑药和双相障碍抑郁相抗抑郁药的使用占比仍较高,其科学性和有效性有待于将来的临床实践论证。
Objective To analyze drug use condition of patients with bipolar disorder in psychiatric outpatient of Anding hospital of Beijing. We compared drug use of patients with bipolar mania with that of bipolar depression,in order to provide reference for clinical rational drug use. Methods Chose 102 cases of clinic patients with bipolar disorder as study subjects, use ratio and dosage to compare the difference of mood stabilizers,atypical anti-psychotics and anti-anxiety drugs,antidepressants in bipolar manic and bipolar depression patients.Results In the 102 patients,77 cases used mood stabilizer,accounting for 75.49%. Patients with bipolar mania used larger dose of valproic acid salt. 93 cases of patients took atypical anti-psychotics,accounting for 91.18%,patients with bipolar mania used quetiapine and olanzapine with large dose. 62 cases used Benzodiazepines anti-anxiety medicine,accounting for 60. 78%,dosage of clonazepam in patients with bipolar mania was higher than patients with bipolar depression. 24 in 78 patients with bipolar depression used antidepressants,accounting for 30. 77%, the use of amphetamine and fluoxetine was greater than other antidepressants.Conclusions Prescriptions for Chinese bipolar disorder patients are basically in line with the guidelines recommended by both domestic and foreign countries. Atypical anti-psychotics are widely used in bipolar mania and bipolar depression patients. Frequency of using Anti-anxiety drug and antidepressants in bipolar depression patients are still high,whose scientificity and effectiveness need to be demonstrated in future clinical practice.
作者
李思聪
姜涛
韩梅
LI Si-cong(Beijing university of traditional Chinese medicine, Beijing, 102488, China)
出处
《齐齐哈尔医学院学报》
2018年第5期556-559,共4页
Journal of Qiqihar Medical University
