摘要
目的探讨前列腺12针经会阴自由手穿刺(FTPB)与20针经会阴模板引导穿刺(TTPB)对PSA<20 ng/ml患者前列腺癌检出率的差异。方法回顾性分析2017年4月至2019年4月上海长海医院768例PSA<20 ng/ml行前列腺穿刺活检患者的临床资料,其中406例行FTPB,为FTPB组;362例行TTPB,为TTPB组。FTPB组和TTPB组的中位年龄[66.00(61.00,70.00)岁与66.00(61.00,71.25)岁]、身高[170.00(165.00,172.00)cm与170(165.00,173.00)cm]、体重[70.00(63.88,75.00)kg与70.00(63.75,75.00)kg]、体质指数[24.22(22.22,25.95)kg/m2与24.22(22.49,25.82)kg/m2]、PSA[8.75(6.49,12.40)ng/ml与8.69(6.49,11.96)ng/ml]、fPSA[1.18(0.33,2.15)ng/ml与1.15(0.76,1.88)ng/ml]、前列腺体积[39.79(25.55,53.94)ml与39.88(24.46,55.11)ml]的差异均无统计学意义(P>0.05)。记录并分析穿刺结果,对比两组的总体前列腺癌检出率、Gleason评分≥7分前列腺癌检出率以及前半区前列腺癌检出率的差异。结果FTPB组和TTPB组总体前列腺癌检出率分别为33.7%(137/406)和39.0%(141/362),差异无统计学意义(P=0.134);Gleason评分≥7分前列腺癌检出率分别为23.9%(97/406)和32.0%(116/362),差异有统计学意义(P=0.012);前半区前列腺癌检出率分别为15.5%(63/406)和27.3%(99/362),差异有统计学意义(P<0.001)。在PSA<10 ng/ml患者中,FTPB组和TTPB组前列腺癌检出率分别为29.8%(74/248)和36.2%(81/224),差异无统计学意义(P=0.144);Gleason评分≥7分前列腺癌检出率分别为19.4%(48/248)和29.9%(67/224),差异有统计学意义(P=0.008)。结论在PSA<20 ng/ml的穿刺患者中,FTPB和TTPB对前列腺癌的总体检出率无明显区别,但TTPB对Gleason评分≥7分前列腺癌的检出率更高,特别是在PSA<10 ng/ml患者中。此外,TTPB对于前半区前列腺癌的检出率也明显高于FTPB。
Objective This retrospective study compared the detection rates of prostate cancer between freehand transperineal biopsy(FTPB) and template-guided transperineal biopsy(TTPB) in the patients with PSA levels<20 ng/ml. Methods From April 2017 to April 2019, 768 patients with PSA levels <20 ng/ml were included into this study. Of these patients, 406 underwent FTPB procedures and 362 underwent TTPB procedures. There were no significant differences of median age [66.00(61.00, 70.00)vs. 66.00(61.00, 71.25)years], height [170.00(165.00, 172.00)vs. 170(165.00, 173.00)cm], weight [70.00(63.88, 75.00)vs. 70.00(63.75, 75.00)kg], BMI [24.22(22.22, 25.95)vs. 24.22(22.49, 25.82)kg/m2], PSA [8.75(6.49, 12.40)vs. 8.69(6.49, 11.96)ng/ml], fPSA [1.18(0.33, 2.15)vs. 1.15(0.76, 1.88)ng/ml], prostate volume [39.79(25.55, 53.94)vs. 39.88(24.46, 55.11)ml] between two groups. Patients’ biopsy results were recorded, the differences of prostate cancer detection rates between these two groups were analyzed, specifically including the cancer with Gleason score≥7 and the anterior zone cancer. Results The total prostate cancer detection rates were 33.7%(137/406) and 39.0%(141/362, P=0.134) in FTPB group and TTPB group respectively, and the detection rates of cancer with Gleason score≥7 were 23.9%(97/406) and 32.0%(116/362, P=0.012) respectively. The detection rates of anterior zone prostate cancer were 15.5%(63/406) and 27.3%(99/362, P<0.001). Moreover, in the patients with PSA <10 ng/ml, the prostate cancer detection rates were 29.8%(74/248) and 36.2%(81/224, P=0.144) respectively, while the detection rates of cancer with Gleason score≥7 were 19.4%(48/248) and 29.9%(67/224, P=0.008) respectively. Conclusions There was no significant difference in the total prostate cancer detection rates between 12-core TTPB group and 20-core FTPB group in the patients with PSA <20 ng/ml, but for the detection rate of cancer with Gleason score≥7, TTPB group was significantly higher than FTPB group, especially in the patients with PSA<10 ng/ml. In ad
作者
林恒之
李沪生
何必鸣
施振凯
曾蜀雄
任冠宇
盛夏
高旭
许传亮
孙颖浩
王海峰
Lin Hengzhi;Li Husheng;He Biming;Shi Zhenkai;Zeng Shuxiong;Ren Guanyu;Sheng Xia;Gao Xu;Xu Chuanliang;Sun Yinghao;Wang Haifeng(Department of Urology, Shanghai Changhai Hospital, Shanghai 200433, China)
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
2019年第8期596-600,共5页
Chinese Journal of Urology
关键词
前列腺肿瘤
诊断
自由手穿刺
模板穿刺
经会阴
Prostatic neoplasms
Diagnosis
Freehand biopsy
Template-guided biopsy
Transperineal
