摘要
目的 分析首都医科大学附属北京友谊医院近8年来前列腺癌的检出状况,了解各危险层级及临床分期前列腺癌的发病情况及变化趋势.方法 回顾性分析2008-2015年首都医科大学附属北京友谊医院1 369例行经直肠B超引导下经会阴前列腺穿刺活检患者的病例资料,按年龄、PSA、穿刺时间、PSAD等指标进行分层分析,探讨不同分层指标下的穿刺阳性率,并对前列腺癌临床分期情况进行总结.2010年前采用14针穿刺,2010年后采用24针穿刺.结果 1 369例中共诊断前列腺癌676例,阳性率49.4%.确诊年龄44 ~91岁,平均(72.9±7.5)岁.2008-2015年每年的穿刺阳性率依次为39.2%(29/74)、41.1%(60/146)、46.9%(45/96)、48.1%(102/212)、48.3%(85/176)、51.4% (126/245)、50.9%(105/206)、57.9%(124/214),2010年后的穿刺阳性率明显提高.<50岁、50 ~59岁、60~69岁、70~ 79岁、≥80岁的阳性率分别为5.3% (1/19)、23.9% (31/130)、40.1%(172/429)、56.0% (342/611)、72.2%(130/180). PSA≤4 μg/L、4.0<PSA≤10.0 μg/L、10.0< PSA≤20.0 μg/L、PSA> 20.0 μg/L组的阳性率分别为16.7%(11/66)、28.6%(113/395)、34.8%(112/322)、81.7% (276/338).PSAD≤0.15组的阳性率为15.9%(45/283)、>0.15组的阳性率为55.3% (267/483).8年间每2年局部低危前列腺癌检出率分别为2.3%(5/220)、2.9% (9/308)、3.1%(13/421)、6.4% (27/420).不同病理分期患者的PSAD分别为T1-2cN0M0期(0.53±0.64),T3-4N0M0期(0.80±0.52),T1-4N1M0期(0.68±0.56),T1-4N0-1M1期(1.53±0.64),T1-4N0-1M1期显著高于其他分期,差异有统计学意义(P<0.05).结论 我院8年来前列腺穿刺活检结果中局部低危前列腺癌检出率逐渐增加.24针穿刺法可显著提高穿刺活检阳性率,且年龄越大、PSA值越高的患者穿刺活检阳性率越高.
Objective To analyse the detection of prostate cancer in Beijing Friendship Hospital,the morbidity of prostate cancer in different stratification and different clinical stages.Methods We retrospectively collected the patients who received transperineal ultrasound guided prostate biopsy (1 369 cases) from 2008 to 2015,and stratified by age,PSA,time of biopsy (14-needle biopsy before 2010 and 24-needle biopsy since 2010),PSAD,explored the biopsy rate in different stratification index and summarized the clinical stage of prostate cancer.Results 676 cases (44-91years old,mean age 72.9 years old) were diagnosed proatate cancer with the positive rate improving obviously after 2010.The prostate cancer detection rates in different groups with ages 0-49 years old,50-59 years old,60-69 years old,70-79 years old,80 years old and above were 5.3% (1/19),23.9% (31/130),40.1% (172/429),56.0% (342/611),72.2% (30/180);with PSA ≤4 μg/L,4.0 < PSA ≤ 10.0 μg/L,10.0 < PSA ≤ 20.0 μg/L,PSA > 20.0 μg/L were 16.7% (11/66),28.6% (113/395),34.8% (112/322),81.7% (276/338);with PSAD less than 0.15,more than 0.15 was 15.9% (45/283),55.3% (267/483).The localized low risk prostate cancer detection rate were 2.3 % (5/220),2.9% (9/308),3.1% (13/421),6.4% (27/420).PSAD of patients with distant metastases is higher than any other stages (P < 0.05),The difference was statistically significant.Conclusions The 24-core transperineal biopsy of prostate may improve the positive rate and the rate is higher in older ages and PSA levels.The localized low risk prostate cancer detection rate increases gradually.
作者
张宇
朱一辰
张峰波
邵强
沈宏亮
吉正国
陈思阳
郭强
田野
Zhang Yu Zhu Yichen Zhang Fengbo Shao Qiang Shen Hongliang Ji Zhengguo Chen Siyang Guo Qiang Tian Ye(Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China)
出处
《中华泌尿外科杂志》
CAS
CSCD
北大核心
2016年第11期819-822,共4页
Chinese Journal of Urology
关键词
前列腺癌
回顾性研究
阳性率
Prostate cancer
Retrospective study
Positive rate