摘要
低温是寒区最主要的非生物性应激原之一,由此导致的冷应激严重影响畜禽生长和生产,给寒区畜牧业造成巨大经济损失。miRNA是一类新型的小分子非编码RNA,广泛参与包括冷应激反应在内的多种生理生化过程的调控。近年来有许多关于在低温条件下发现生物体内存在大量差异表达miRNA的研究报道,这些差异表达的miRNA也被称之为冷应激miRNA(CryomiRs)。冷应激miRNA在冬眠、冷冻、低温和低体温动物的多种组织中被大量发现,因此这些miRNA在帮助动物应对低温引起的冷应激方面可能发挥重要作用。新兴的研究表明,应激可以改变miRNA的生物合成,miRNA靶基因的表达以及miRNA-蛋白复合物的活性。冷应激miRNA的发现和功能探究将为冷应激状态的评价及冷应激发生机制的研究提供新的思路。
Low temperature was one of the most important abiotic stressors in cold regions, resulting in severe cold stress affecting the growth and production of livestock and poultry, causing huge economic losses to livestock husbandry in cold regions. miRNA was a new type of small molecule non -coding RNA which was widely involved in many physiological and biochemical processes including cold stress response. In recent years, there were many reports on the discovery of a large number of differentially expressed miRNAs in living organisms at low temperature. These differentially expressed miRNA were called cold-stressed miRNA(CryomiR). CryomiR was found in many tissues of hibernating, freezing, cryogenic, and hypothermic animals, so these miRNA may play an important role in helping the animals to cope with cold stress caused by low temperature. Emerging studies showed that stress could alter the biosynthesis of miRNAs, the expression of miRNA target genes and the activity of miRNAs -protein complexes. The discovery and functional exploration of cold stress miRNAs would provide new ideas for the evaluation of cold stress state and the study of cold stress excitation mechanism.
作者
甄莉
陈勇
杨海明
臧树成
郭丽
计红
杨焕民
Zhen Li;Chen Yong;Yang Haiming;Zang Shucheng;Guo Li;Ji Hong;Yang Huanmin(College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319)
出处
《黑龙江八一农垦大学学报》
2019年第4期28-32,共5页
journal of heilongjiang bayi agricultural university
基金
国家自然科学基金（31372398）
校内培育课题（XZR2015-05）
大庆市科技项目（ZD-2017-25）
